Motor and cognitive impairments in spinocerebellar ataxia type 7 and its correlations with cortical volumes

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dc.contributor.author Gálvez Zúñiga, Víctor Hugo
dc.creator VICTOR HUGO GALVEZ ZUÑIGA:421958
dc.date.accessioned 2018-10-12T16:26:54Z
dc.date.available 2018-10-12T16:26:54Z
dc.date.issued 2018-09-26
dc.identifier.citation Chirino, A., Hernández Castillo, C. R., Gálvez Zúñiga,V. H., Contreras, A., Díaz, R., Beltrán Parrazal L. y Fernández Ruíz J. (2018). Motor and cognitive impairments in spinocerebellar ataxia type 7 and its correlations with cortical volumes. European Journal of Neuroscience. DOI : 10.1111/ejn.14148 es_ES, en_US
dc.identifier.issn 0953-816X es_ES, en_US
dc.identifier.other Campus Ciudad de México es_ES, en_US
dc.identifier.uri http://scripta.up.edu.mx/xmlui/handle/123456789/4713
dc.identifier.uri http://dx.doi.org/10.1111/ejn.14148
dc.description.abstract Spinocerebellar Ataxia Type 7 (SCA7) is a neurodegenerative disorder caused by cytosine-adenine-guanine (CAG) repeat expansion. It is clinically characterized by ataxia and visual loss. To date, little is known about SCA7 cognitive impairments and its relationship with grey matter volume (GMV) changes. The aim of this study was to explore SCA7 patients’ performance in specific components of auditory-verbal neuropsychological tests and to correlate their scores with genetic mutation, severity of ataxia and GMV. We assessed verbal memory and verbal fluency proficiencies in 31 genetically confirmed SCA7 patients, and compared their results with 32 healthy matched volunteers; we also correlated CAG repeats and severity of motor symptoms with performance in the auditory-verbal tests. SCA7 patients exhibited deficiencies in several components of these cognitive tasks, which were independent of motor impairments and showed no relation to CAG repeats. Based on Resonance Images performed in 27 patients we found association between ataxia severity and GMV in “sensoriomotor” cerebellum, as well as correlations of impaired verbal memory and semantic fluency scores with GMV in association cortices, including the right parahippocampal gyrus. To our knowledge, this is the first report of deficits in the organization of semantic information and in the evocation of verbal material, as well as greater susceptibility to proactive interference in SCA7 patients. These findings bring novel information about specific cognitive abilities in SCA7 patients, particularly verbal memory and fluency, and their relation with GMV variations in circumscribed brain regions, including association cortices known to have functional relationships with the cerebellum. © 2018 Federation of European Neuroscience Societies and John Wiley & Sons Ltd. es_ES, en_US
dc.description.tableofcontents Ciencias de la Salud es_ES, en_US
dc.language eng es_ES, en_US
dc.publisher Blackwell Publishing Ltd. es_ES, en_US
dc.relation Versión aceptada es_ES, en_US
dc.relation.ispartof REPOSITORIO SCRIPTA es_ES, en_US
dc.relation.ispartof OPENAIRE es_ES, en_US
dc.rights Acceso Embargado es_ES, en_US
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0 es_ES, en_US
dc.rights.uri http://www.sherpa.ac.uk/romeo/issn/0953-816X/
dc.source European Journal of Neuroscience
dc.subject Autosomal dominant ataxia es_ES, en_US
dc.subject Cognitive impairments es_ES, en_US
dc.subject Motor impairments es_ES, en_US
dc.subject Volumetric magnetic resonance es_ES, en_US
dc.subject.classification MEDICINA Y CIENCIAS DE LA SALUD es_ES, en_US
dc.title Motor and cognitive impairments in spinocerebellar ataxia type 7 and its correlations with cortical volumes es_ES, en_US
dc.type Artículo es_ES, en_US
dcterms.audience Investigadores
dcterms.audience Estudiantes
dcterms.audience Maestros


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