The conception, design, and construction of classroom space in education has under-gone transformations throughout history; it has moved from a traditional space in which functionality, sunlight, ventilation, and scale were privileged, to another design under the COVID-19 context in which priority is given to flexibility, recalculation of capacity, air circulation and open spaces. The objective of this research is to conduct a systematic literature review that contemplates empirical research on classroom space configuration in education during the period from 2015 to 2021. The following were considered as inclusion criteria: articles addressing the topic of the classroom space for learning; publications between 2015-2021 and conducted in the context of Ibero America. The open access databases SCIELO, REDALYC and search engines such as INVENTIO were used. In total, a database of 111 articles was compiled, from which 18 selected articles were filtered based on the inclusion criteria. The results were analyzed based on the content analysis strategy. Eight of the research were identified from Spain, 3 from Mexico, 3 from Colombia, 1 from Peru, 1 from Ecuador, 1 from Venezuela and 1 from Panama. It is concluded that there is a need to create classroom spaces that meet the criteria of limited capacity and ventilation for the COVID-19 context without neglecting the use of strategies that promote collaborative learning.