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Ramírez Muciño, José Arturo
Tuberous Sclerosis Complex
Phimosis: A rare complication of immunotherapy with durvalumab
2022
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Vázquez-Lavista, Luis Gabriel
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Ramírez Muciño, José Arturo
,
López-Almanza, Perla Ximena
,
Janka-Zires, Marcela
A 38-year-old woman arrived at the emergency department complaining of left lower back pain, nausea, malaise, and mild chest discomfort. On physical examination she was pale and had multiple skin fibromas. Her abdominal exam was benign, and she was vitally stable. Her heart rate was 90 beats per minute. Labs were notable with a reported hemoglobin level of 9 mg/dl. Given her symptoms, a CT of her chest, abdomen and pelvis was performed. A bleeding angiomyolipoma on the left kidney was identified (Fig. 1), along with a hyperdense lesion on the base of the left lung, compatible with incipient pulmonary lymphangiomyomatosis. © Urology
2020
,
Vázquez-Lavista, Luis Gabriel
,
Llorente, Luis
,
Alatorre-Alexander, Jorge
,
Ramírez Muciño, José Arturo
We present a case of a 69 year old man with phimosis associated with immunotherapy with durvalumab for metastatic non-small-cell lung cancer. The patient developed vitiligo like dermatosis after the induction dose of durvalumab, subsequent administration of the immunotherapy the patient developed a fibrous ring of the foreskin. Immune-mediated adverse reactions have been described after the use of durvalumab, but, to our knowledge, there are no reports of phimosis and vitiligo like reactions. © 2020 The Authors