Delayed injection of polypyrrole doped with iodine particle suspension after spinal cord injury in rats improves functional recovery and decreased tissue damage evaluated by 3.0 Tesla in vivo magnetic resonance imaging
Journal
The Spine Journal
ISSN
1529-9430
Date Issued
2017
Author(s)
Mondragón-Lozano, Rodrigo
Ríos, Camilo
Cruz, Guillermo J.
Olayo, Maria G.
Olayo, Roberto
Salgado-Ceballos, Hermelinda
Morales, Juan
Mendez-Armenta, Marisela
Alvarez-Mejia, Laura
Fabela, Omar
Morales-Guadarrama, Axayacatl
Sánchez-Torres, Stephanie
Diaz-Ruiz, Araceli
Type
Resource Types::text::journal::journal article
Abstract
Background context: Traumatic spinal cord injury (SCI) causes irreversible damage with loss of motor, sensory, and autonomic functions. Currently, there is not an effective treatment to restore the lost neurologic functions. Purpose: Injection of polypyrrole-iodine(PPy-I) particle suspension is proposed as a therapeutic strategy. Study design: This is an in vivo animal study. Methods: This study evaluates the use of such particles in rats after SCI by examining spared nervous tissue and the Basso, Beattie, and Bresnahan (BBB) scale to evaluate the functional outcome. Diffusive magnetic resonance imaging (MRI) was employed to measure the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) as non-invasive biomarkers of damage after SCI. Copyright © 2016 Elsevier Inc. All rights reserved.