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Characterization of a murine model of endothelial dysfunction induced by chronic intraperitoneal administration of angiotensin II
Journal
Scientific Reports
ISSN
2045-2322
Date Issued
2021
Author(s)
Trejo-Moreno, Celeste
Jiménez-Ferrer, Enrique
Castro-Martínez, Gabriela
Méndez-Martínez, Marisol
Santana, María Angélica
Pedraza-Chaverri, José
Medina-Campos, Omar Noel
Hernández-Téllez, Beatriz
Ramírez-Pliego, Oscar
Herrera-Ruiz, Maribel
Cervantes-Torres, Jacquelynne
Alvarado-Ojeda, Zimri Aziel
Costet-Mejía, Alejandro
Fragoso, Gladis
Rosas-Salgado, Gabriela
Type
Resource Types::text::journal::journal article
Abstract
Endothelial dysfunction (ED) is a key factor for the development of cardiovascular diseases. Due to its chronic, life-threatening nature, ED only can be studied experimentally in animal models. Therefore, this work was aimed to characterize a murine model of ED induced by a daily intraperitoneal administration of angiotensin II (AGII) for 10 weeks. Oxidative stress, inflammation, vascular remodeling, hypertension, and damage to various target organs were evaluated in treated animals. The results indicated that a chronic intraperitoneal administration of AGII increases the production of systemic soluble VCAM, ROS and ICAM-1 expression, and the production of TNFα, IL1β, IL17A, IL4, TGFβ, and IL10 in the kidney, as well as blood pressure levels; it also promotes vascular remodeling and induces non-alcoholic fatty liver disease, glomerulosclerosis, and proliferative retinopathy. Therefore, the model herein proposed can be a representative model for ED; additionally, it is easy to implement, safe, rapid, and inexpensive.