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Arthroscopic Matrix-Assisted Autologous Chondrocyte Transplantation Versus Microfracture: A 6-Year Follow-up of a Prospective Randomized Trial
Journal
The American Journal of Sports Medicine
ISSN
0363-5465
1552-3365
Date Issued
2021
Author(s)
Ibarra, Clemente
Villalobos, Enrique
Madrazo-Ibarra, Antonio
Velasquillo, Cristina
Martínez-López, Valentín
Izaguirre, Aldo
Olivos-Meza, Anell
Cortes-Gonzalez, Socorro
Pérez-Jiménez, Francisco Javier
Vargas-Ramirez, Alberto
Franco-Sánchez, Gilberto
Ibarra-Ibarra, Luis Guillermo
Sierra-Suarez, Luis
Almazán, Arturo
Ortega-Sánchez, Carmina
Trueba, Cesáreo
Barbosa Martin, Fernando
Arredondo-Valdes, Reynaldo
Chávez- Arias, Daniel
Type
Resource Types::text::journal::journal article
Abstract
Background:
Few randomized controlled trials with a midterm follow-up have compared matrix-assisted autologous chondrocyte transplantation (MACT) with microfracture (MFx) for knee cartilage lesions.
Purpose:
To compare the structural, clinical, and safety outcomes at midterm follow-up of MACT versus MFx for treating symptomatic knee cartilage lesions.
Study Design:
Randomized controlled trial; Level of evidence, 1.
Methods:
A total of 48 patients aged between 18 and 50 years, with 1- to 4-cm2 International Cartilage Repair Society (ICRS) grade III to IV knee chondral lesions, were randomized in a 1:1 ratio to the MACT and MFx treatment groups. A sequential prospective evaluation was performed using magnetic resonance imaging (MRI) T2 mapping, the MOCART (magnetic resonance observation of cartilage repair tissue) score, second-look arthroscopic surgery, patient-reported outcome measures, the responder rate (based on achieving the minimal clinically important difference for the Knee injury and Osteoarthritis Outcome Score [KOOS] pain and KOOS Sport/Recreation), adverse events, and treatment failure (defined as a reoperation because of symptoms caused by the primary defect and the detachment or absence of >50% of the repaired tissue during revision surgery).
Few randomized controlled trials with a midterm follow-up have compared matrix-assisted autologous chondrocyte transplantation (MACT) with microfracture (MFx) for knee cartilage lesions.
Purpose:
To compare the structural, clinical, and safety outcomes at midterm follow-up of MACT versus MFx for treating symptomatic knee cartilage lesions.
Study Design:
Randomized controlled trial; Level of evidence, 1.
Methods:
A total of 48 patients aged between 18 and 50 years, with 1- to 4-cm2 International Cartilage Repair Society (ICRS) grade III to IV knee chondral lesions, were randomized in a 1:1 ratio to the MACT and MFx treatment groups. A sequential prospective evaluation was performed using magnetic resonance imaging (MRI) T2 mapping, the MOCART (magnetic resonance observation of cartilage repair tissue) score, second-look arthroscopic surgery, patient-reported outcome measures, the responder rate (based on achieving the minimal clinically important difference for the Knee injury and Osteoarthritis Outcome Score [KOOS] pain and KOOS Sport/Recreation), adverse events, and treatment failure (defined as a reoperation because of symptoms caused by the primary defect and the detachment or absence of >50% of the repaired tissue during revision surgery).