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Validation of an equation for free calcium estimation: accuracy improves after adjustment for phosphate and CO2
Journal
International Urology and Nephrology
ISSN
1573-2584
Date Issued
2022
Author(s)
Ramirez-Sandoval, Juan C.
Diener-Cabieses, Pablo
Gutiérrez-Valle, Fabián
Ley-Tapia, Sofía
Pastrana-Brandes, Santiago
Galindo, Pablo E.
Fagundo, Reynerio
Moreno-Yañez, Mauricio
Reza-Albarrán, Alfredo Adolfo
Correa-Rotter, Ricardo
Type
Resource Types::text::journal::journal article
Abstract
Purpose: Free calcium is the gold standard for diagnosis of calcium disorders, although calcium assessment is routinely performed by albumin-adjusted calcium. Our objective was to develop a novel-specific correction equation for free calcium employing serum total calcium and other analytes. Methods: Retrospective single-center cohort study. A new equation for free calcium assessment was formulated from data of hospitalized patients (n = 3481, measurements = 7157) and tested in a validation cohort (n = 3218, measurements = 6911). All measurements were performed simultaneously from the same blood draw. © International Urology and Nephrology