Ortíz Hidalgo, Carlos FedericoCarlos FedericoOrtíz Hidalgo2025-04-242025-04-242025Ortiz-Hidalgo, C. (2025). History of Leukemia, Revisited. Current Oncology Reports, 27(4), 472–482. https://doi.org/10.1007/s11912-025-01658-2https://scripta.up.edu.mx/handle/20.500.12552/1208310.1007/s11912-025-01658-2Purpose of the Review: Provide a general historical overview of leukemia, emphasizing the early discoveries that led to its characterization. Recent Findings: Leukemia recognition began in the late 19th century with the advent of the microscope. Leeuwenhoek and Swammerdam described erythrocytes, while Lieutaud first observed globuli albicantes, later identified as lymphocytes by Hewson. Early case studies by Velpeau, Donné, Bennett, Craigie, Virchow, and Fuller suggested that leukocytosis could occur without infection. Virchow coined the term “leukemia,” while Bennett proposed “leucocythemia.” Neumann identified the bone marrow as the source of blood cells and leukemia, coining the term “myelogenous leukemia,” and Ehrlich classified leukemia into myeloid and lymphoid types. In 1914, Boveri linked chromosomal abnormalities to cancer, and in 1960, Nowell and Hungerford discovered the Philadelphia chromosome. The use of mustard gas in WWI led to the development of chemotherapy drugs like chlorambucil and busulfan. The Human Genome Project further advanced leukemia diagnosis and treatment. Summary: Leukemia, like many diseases, has evolved due to changes in causative factors such as viruses, bacteria, and genetic mutations, which have impacted its pathogenesis and treatment. It will undoubtedly continue to evolve, with new scientists working towards a cure for this devastating disease. ©The author ©Current Oncology Reports ©Springer Science and Business Media LLC.Thomas X. First contributors in the history of leukemia. World J Hematol 2013;2: 62–70. Doi: https://doi.org/10.5315/wjh.v2.i3.62. Kampen KR. The discovery and early understanding of leukemia. Leuk Res 2012;36:6–13. doi: https://doi.org/10.1016/j.leukres.2011.09.028. Seufert W, Seufert WD. The recognition of leukemia as a systemic disease. J Hist Med Allied Sci 1982;37:34–50. Freireich EJ, Wiernik PH, Steensma DP. The leukemias: a half-century of discovery. J Clin Oncol. 2014;32:3463-9. doi: https://doi.org/10.1200/JCO.2014.57.1034. These four articles are among the most comprehensive accounts of the history and evolution of leukemia. Kay AB. 2016. Paul Ehrlich and the Early History of Granulocytes. Microbiol Spectr 4: https://doi.org/10.1128/microbiolspec.mchd-0032-2016. https://doi.org/10.1128/microbiolspec.mchd-0032-2016. According to many historians, Paul Ehrlich is one of the most important researchers in history, and this article accurately highlights his discoveries in blood histology that contributed to the understanding of leukemia. Boveri T. Concerning the origin of malignant tumours by Theodor Boveri. Translated and annotated by Henry Harris. J Cell Sci. 2008;121 Suppl 1:1–84. doi: https://doi.org/10.1242/jcs.025742. This influential book on human genetics was written by Theodore H. Boveri, one of the leading scientists of the second half of the nineteenth century. His groundbreaking work on chromosomal structures and function laid the foundation for understanding chromosomal abnormalities in various tumors, including leukemia. Mukherjee, S. The emperor of all maladies: a biography of cancer. Large print ed. Waterville, Me., Thorndike Press 2010. This book can be considered the definitive reference on the history of leukemia. DeVita VT Jr, Chu E. A history of cancer chemotherapy. Cancer Res 2008;68:8643-53. doi: https://doi.org/10.1158/0008-5472.CAN-07-6611. This article is undoubtedly a significant contribution to the history of chemotherapy.enAcceso AbiertoHistory of leukemiaRudolf VirchowJohn H BennettSydney Farbertext::journal::journal article