Brooks, DennisDennisBrooksLinares-Alba, Monica AnayatzinMonica AnayatzinLinares-AlbaGarcia-Santisteban, RodrigoRodrigoGarcia-SantistebanXie, EnliEnliXieGum, GlenwoodGlenwoodGumManza, Linda L.Linda L.ManzaServitje-Azcarraga, LucilaLucilaServitje-AzcarragaSantisteban, Diego G.Diego G.SantistebanGarcía-Sánchez, Gustavo AdolfoGustavo AdolfoGarcía-Sánchez2023-07-172023-07-172022https://scripta.up.edu.mx/handle/20.500.12552/393310.1089/jop.2022.0030Purpose: To determine the pharmacokinetics of a proprietary liposomal sirolimus (LS) formulation in ocular tissues and plasma following a single subconjunctival (SCJ) injection in Dutch belted rabbits (DBR). Analytical methods for detection of LS in plasma, aqueous humor (AH), vitreous humor (VH), retina, combined retina/choroid/retinal pigment epithelium, sclera, and iris/ciliary body were developed to examine samples. Methods: Thirty male DBR were subconjunctivally injected in both eyes with 0.1 mL of LS of 1,000 μg/mL. At selected times post-injection, ocular tissues and whole blood samples were obtained. Sirolimus concentrations were measured using liquid chromatography/tandem mass spectrometry.enLiposomesOcular tissueSirolimusPharmacokinetics of Sirolimus in a Novel Liposome Delivery System in Selected Ocular Tissues and Plasma Following a Single Subconjunctival Injection in Dutch Belted RabbitsResource Types::text::journal::journal article