Ortega-Romero, ManoloManoloOrtega-RomeroMéndez-Hernández, PabloPabloMéndez-HernándezCruz-Angulo, María del CarmenMaría del CarmenCruz-AnguloHernández-Sánchez, Ana MaríaAna MaríaHernández-SánchezÁlvarez-Elías, Ana CatalinaAna CatalinaÁlvarez-ElíasMuñoz-Arizpe, RicardoRicardoMuñoz-ArizpeSales-Heredia, FranciscoFranciscoSales-HerediaAguilar-Madrid, GuadalupeGuadalupeAguilar-MadridJuárez-Perez, Cuauhtémoc ArturoCuauhtémoc ArturoJuárez-PerezSoto, VirgiliaVirgiliaSotoValadés, TeresaTeresaValadésOlvera-Rivas, NadiaNadiaOlvera-RivasObrador, GregorioGregorioObradorBarbier, Olivier C.Olivier C.BarbierMayo Maldonado, JonathanJonathanMayo Maldonado2022-11-242022-11-242019https://scripta.up.edu.mx/handle/20.500.12552/209510.1159/000502481Introduction: Tlaxcala, a small state in central Mexico, has the highest prevalence of chronic kidney disease (CKD) deaths in population aged 5-14 in Mexico, most of them with unknown etiology. Objective: To determine the prevalence of CKD in apparently healthy pediatric population in Apizaco, Tlaxcala. Methods: A cross-sectional pilot study was carried out in children deemed as healthy; subjects with previous diagnosis of CKD were excluded. Informed consent was obtained in all cases. A physical examination was performed, a questionnaire was applied. Blood and urine samples were obtained for serum creatinine, urinalysis, and microalbumin/creatinine ratio. A second and third evaluation was performed after 6 and 18 months in those found with urinary anomalies/CKD to confirm the diagnosis. Results: One hundred and nine subjects completed physical examination, which are the biological samples. Median age was 12 years. CKD stage 2 was confirmed in 5 subjects in the sixth month confirmation visit (4.6%). One patient accepted renal biopsy and Alport Syndrome was found. In a robust multivariate analysis, the risk factors related to reduction in the glomerular filtration rate were males -5.15 mL/min/1.73 m2 (p = 0.002), older participants as by -1.58 mL/min/1.73 m2 per year (p < 0.0001), and among participants living close to a river -3.76 mL/min/1.73 m2 (p = 0.033). Discussion/Conclusion: The prevalence of CKD in the population studied in Apizaco Tlaxcala was confirmed in 4.6 cases per 100 inhabitants between 6 and 15 years. Males, older age, and living close to a river were the risk predictive factors. More studies are needed to determine the causes of the high CKD prevalence in this population. ©2019 S. Karger AG, Basel.enChronic kidney diseasePediatricsUrinary anomaliesCreatinineAlport syndromeBlood samplingBody massChild urologyChildhood obesityChronic kidney failureCreatinine blood levelCross-sectional studyResource Types::text::journal::journal article