García-Delgado, C.C.García-DelgadoBahena-Martínez, E.E.Bahena-MartínezAparicio-Onofre, A.A.Aparicio-OnofreGuevara-Yañez, R.R.Guevara-YañezCervantes-Peredo, A.A.Cervantes-PeredoAzotla-Vilchis, O. C.O. C.Azotla-VilchisEstrada Mena, Francisco JavierFrancisco JavierEstrada MenaLuna-Angulo, AlexandraAlexandraLuna-AnguloVilla-Morales, J.J.Villa-MoralesMorrán-Barroso, V. F.V. F.Morrán-Barroso2023-01-262023-01-262010https://scripta.up.edu.mx/handle/20.500.12552/2436The concurrence of a reciprocal translocation and an aneuploidy represent a rare coincidence and an interchromosome effect between these two events has been suggested. We report the case of a family with a t(1;15) in three generations which was identified through the evaluation ofa patient with classical trisomy 21 or Down syndrome. The cytogenetic analysis with GTG banding showed that the proband had a regular trisomy 21 and a balanced translocation t(1;15). FISH and microsatellite analysis were carried out in the family in order to discard an interchromosomal effect. The implications for genetic assessment are discussed. © Genetic CounselingenResource Types::text::journal::journal article