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Author: search.filters.author.Blackorby, AllisonSubject: search.filters.subject.Anaemia

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    Item type:Publication,
    The ASCEND-ND trial: study design and participant characteristics
    (2021)
    Perkovic, Vlado
    ;
    Blackorby, Allison
    ;
    Cizman, Borut
    ;
    Carroll, Kevin
    ;
    Cobitz, Alexander R.
    Background: Anaemia is common in chronic kidney disease (CKD) and assessment of the risks and benefits of new therapies is important. Methods: The Anaemia Study in CKD: Erythropoiesis via a Novel prolyl hydroxylase inhibitor Daprodustat-Non-Dialysis (ASCEND-ND) trial includes adult patients with CKD Stages 3-5, not using erythropoiesis-stimulating agents (ESAs) with screening haemoglobin (Hb) 8-10 g/dL or receiving ESAs with screening Hb of 8-12 g/dL. Participants were randomized to daprodustat or darbepoetin alfa (1:1) in an open-label trial (steering committee- and sponsor-blinded), with blinded endpoint assessment. The co-primary endpoints are mean change in Hb between baseline and evaluation period (average over Weeks 28-52) and time to first adjudicated major adverse cardiovascular (CV) event. Baseline characteristics were compared with those of participants in similar anaemia trials. © The Author(s) 2021. Published by Oxford University Press on behalf of the ERA.
    Scopus© Citations 6  15  1