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Real-Life Impact of Enfortumab Vedotin or Chemotherapy in the Sequential Treatment of Advanced Urothelial Carcinoma: The ARON-2 Retrospective Experience
(Wiley, 2025)
Rizzo, Mimma
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Morelli, Franco
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Ürün, Yüksel
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Buti, Sebastiano
;
Park, Se Hoon
Background: Recently, a plethora of novel systemic agents have been incorporated into the therapeutic armamentarium of advanced urothelial carcinoma (aUC). The antibody–drug conjugate (ADC), enfortumab vedotin (EV), has demonstrated relevant clinical benefit in patients with aUC refractory to platinum and immune-checkpoint inhibitor (ICI) therapy. Our study provides a retrospective, international, real-world analysis comparing the effectiveness of EV to chemotherapy in this setting. Methods: The data were extracted from the medical records of patients treated with EV or chemotherapy following pembrolizumab for recurrent or progressive aUC after platinum-based chemotherapy. Patients were assessed for overall survival (OS), progression-free survival (PFS), overall response rate (ORR) and duration of response (DoR). Results: Our analysis included 247 patients treated with EV (88, 36%) or chemotherapy (159, 64%). Median OS was 9.1 months (95%CI 7.2–10.7) in the overall study population, 13.6 months (95%CI 10.0–31.0) in patients receiving EV and 6.8 months (95%CI 6.0–8.9) in patients receiving chemotherapy (p < 0.001). The OS benefit of EV was not affected by primary tumour site and histology, metastatic sites, type of first platinum-based chemotherapy or response to pembrolizumab. In the EV cohort, the median PFS was significantly longer (8.8 months [95%CI 6.5–17.0] vs. 3.0 months [95%CI 2.6–3.7]) and the ORR was significantly higher (56% vs. 23%) than in the chemotherapy cohort. ©The authors ©Wiley ©Cancer Medicine.
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Enfortumab Vedotin Following Platinum Chemotherapy and Avelumab Maintenance in Patients with Metastatic Urothelial Carcinoma: A Retrospective Data from the ARON-2EV Study
(2024)
Fiala, Ondřej
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Massari, Francesco
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Basso, Umberto
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Giannatempo, Patrizia
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Grande, Enrique
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Pembrolizumab in Patients with Advanced Urothelial Carcinoma with ECOG Performance Status 2: A Real-World Study from the ARON-2 Project
(2024)
Alessandro Rizzo
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Fernando Sabino Marques Monteiro
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Yüksel Ürün
;
Francesco Massari
;
Se Hoon Park
15
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Differences in the expression of the phosphatase PTP-1B in patients with localized prostate cancer with and without adverse pathological features
(2024)
Bourlon de los Ríos, María Teresa
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Shaddai Urbina-Ramirez
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Haydee C. Verduzco-Aguirre
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Mauricio Mora-Pineda
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Hugo E. Velazquez
<jats:sec><jats:title>Introduction</jats:title><jats:p>Patients with adverse pathological features (APF) at radical prostatectomy (RP) for prostate cancer (PC) are candidates for adjuvant treatment. Clinicians lack reliable markers to predict these APF preoperatively. Protein tyrosine phosphatase 1B (PTP-1B) is involved in migration and invasion of PC, and its expression could predict presence of APF. Our aim was to compare PTP-1B expression in patients with and without APF, and to explore PTP-1B expression as an independent prognostic factor.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Tissue microarrays (TMAs) were constructed using RP archival specimens for immunohistochemical staining of PTP-1B; expression was reported with a standardized score (0-9). We compared median PTP-1B score between cases with and without APF. We constructed two logistic regression models, one to identify the independence of PTP-1B score from biologically associated variables (metformin use and type 2 diabetes mellitus [T2DM]) and the second to seek independence of known risk factors (Gleason score and prostate specific antigen [PSA]).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 73 specimens were suitable for TMA construction. Forty-four (60%) patients had APF. The median PTP-1B score was higher in those with APF: 8 (5-9) vs 5 (3-8) (p=0.026). In the logistic regression model including T2DM and metformin use, the PTP-1B score maintained statistical significance (OR 1.21, 95% CI 1.01-1.45, p=0.037). In the model including PSA and Gleason score; the PTP-1B score showed no independence (OR 1.68, 95% CI 0.97-1.41, p=0.11). The area under the curve to predict APF for the PTP-1B score was 0.65 (95% CI 0.52-0.78, p=0.03), for PSA+Gleason 0.71 (95% CI 0.59-0.82, p=0.03), and for PSA+Gleason+PTP-1B score 0.73 (95% CI 0.61-0.84, p=0.001).</jats:p></jats:sec><jats:sec><jats:title>Discussion</jats:title><jats:p>Patients with APF after RP have a higher expression of PTP-1B than those without APF, even after adjusting for T2DM and metformin exposure. PTP-1B has a good accuracy for predicting APF but does not add to known prognostic factors.</jats:p></jats:sec>
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Tomografía por emisión de positrones
(Colegio de Medicina Interna de México AC, 2007-07-01)
Coronel Ayala, Omar Francisco
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Serna Macías, José Antonio
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Bourlon Cuellar, René
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Bourlon de los Ríos, María Teresa
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Gómez Sámano, Miguel Ángel
Toda enfermedad tiene una historia natural y su evolución se debe a diferentes procesos biológicos. Uno de estos incluye el proceso dinámico, del cual no pueden obtenerse las imágenes que reflejan la actividad corporal, a menos que se realice alguna determinación metabólica y se compare con el resto de las funciones fisiológicas. En este contexto, la tomografía por emisión de positrones proporciona información de dichos procesos y ofrece un punto de vista diferente del resto de las modalidades de imagen. La finalidad de la tomografía por emisión de positrones es producir imágenes que ilustren la función fisiológica y específica de algún proceso molecular; por lo tanto, se utiliza para determinar el metabolismo de la glucosa, la perfusión y el flujo sanguíneo, la tasa de unión de los complejos receptor-ligando y el intercambio de oxígeno. Con estas imágenes se distinguen los estados funcionales, normales o alterados, de alguna estructura específica. En comparación con la medicina nuclear, la tomografía por emisión de positrones utiliza radiofármacos (radiotrazadores marcados), como: carbono, oxígeno, nitrógeno y flúor (elementos básicos de los sustratos biológicos). Estos isótopos se parecen a los sustratos naturales como azúcares, agua, proteínas y oxígeno. Dicha técnica modifica la tasa costo-beneficio en el área de la oncología, cardiología y neurología para el tratamiento del paciente, además de proporcionar las siguientes ventajas: a) diagnosticar enfermedades antes que se produzcan cambios estructurales; b) vigilar la respuesta al tratamiento; c) pronosticar procedimientos quirúrgicos innecesarios, y d) detectar metástasis distantes u ocultas. ©Medicina Interna de México.
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Overview and characterization of penile cancer content across social media platforms
(Frontiers Media, 2023)
Ortiz-Guerra, Ruben Alejandro
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Jaime-Casas, Salvador
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Martinez-Cannon, Bertha Alejandra
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Ariza-Avila, Jose C.
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González-Morales, Ana P.
Background: Social media platforms (SMP) are an emerging resource that allows physicians, patients, and families to converse on cancer prevention, diagnosis, and treatment. We aimed to characterize penile cancer (PC) content shared on SMP. Methods: We searched PC posts on Twitter, Facebook, and Instagram from July 1st, 2021, through June 30th, 2022. Two independent, blinded reviewers analyzed the hashtags: #PenileCancer, #PenileCancerAwareness, and #PenileNeoplasm. Descriptive statistics were used for posts characterization, Pearson´s correlation coefficient for associations, and Cohen’s weighted kappa coefficient for inter-rater agreement rate. ©Frontiers Media
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