CRIS

Permanent URI for this communityhttps://scripta.up.edu.mx/handle/20.500.12552/1

Browse

Settings

Author: search.filters.author.Domínguez-Pérez, Dany

Search Results

Now showing 1 - 2 of 2
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Editorial: Harnessing marine biodiversity for novel antimicrobial agents against multidrug-resistant pathogens
    (Frontiers Media SA, 2025)
    Agüero-Chapin, Guillermin
    ;
    Domínguez-Pérez, Dany
    ;
    Marrero Ponce, Yovani  
    Antimicrobial resistance (AMR) is a defining challenge of our era, responsible for an alarming number of deaths that now surpass those caused by HIV and malaria. Projections estimate that by 2050, AMR could lead to 10 million deaths annually. The COVID19 pandemic has amplified this crisis, fueling the spread of multidrug-resistant (MDR) pathogens, particularly those associated with biofilms. In response, governments have begun adopting more agile investment models, while academia and emerging biotech initiatives play increasingly central roles in the discovery of next-generation antimicrobials. The ocean, covering over 70% of Earth’s surface, represents an extraordinary yet underexploited reservoir of chemical diversity. Marine ecosystems harbor a vast array of microorganisms and multicellular life forms adapted to extreme and varied habitats. These organisms, from actinomycetes to fish and fungi, produce structurally unique secondary metabolites as chemical defenses or communication tools—many of which exhibit promising antimicrobial activities. This Research Topic aims to showcase the potential of marine biodiversity in providing new solutions to counteract MDR pathogens. © The authors © Frontiers Media.
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Unveiling Encrypted Antimicrobial Peptides from Cephalopods' Salivary Glands: A Proteolysis-Driven Virtual Approach
    (American Chemical Society, 2024)
    Agüero-Chapin, Guillermin
    ;
    Domínguez-Pérez, Dany
    ;
    Marrero Ponce, Yovani  
    ;
    Castillo-Mendieta, Kevin
    ;
    Antunes, Agostinho
    Antimicrobial peptides (AMPs) have potential against antimicrobial resistance and serve as templates for novel therapeutic agents. While most AMP databases focus on terrestrial eukaryotes, marine cephalopods represent a promising yet underexplored source. This study reveals the putative reservoir of AMPs encrypted within the proteomes of cephalopod salivary glands via in silico proteolysis. A composite protein database comprising 5,412,039 canonical and noncanonical proteins from salivary apparatus of 14 cephalopod species was subjected to digestion by 5 proteases under three protocols, yielding over 9 million of nonredundant peptides. These peptides were effectively screened by a selection of 8 prediction and sequence comparative tools, including machine learning, deep learning, multiquery similarity-based models, and complex networks. The screening prioritized the antimicrobial activity while ensuring the absence of hemolytic and toxic properties, and structural uniqueness compared to known AMPs. Five relevant AMP datasets were released, ranging from a comprehensive collection of 542,485 AMPs to a refined dataset of 68,694 nonhemolytic and nontoxic AMPs. Further comparative analyses and application of network science principles helped identify 5466 unique and 808 representative nonhemolytic and nontoxic AMPs. These datasets, along with the selected mining tools, provide valuable resources for peptide drug developers. ©The authors ©ACS Omega.
    Scopus© Citations 1  13