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Extended major histocompatibility complex haplotypes, ancestry and acute kidney transplant rejection in Mexicans
(2011-07)
Riquelme Mc Loughlin, M. Constanza
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Granados, Julio
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Acuña-Alonzo, Víctor
;
Telich, Eduardo
;
Mancilla-Urrea, Eduardo
Introduction. Extended major histocompatibility complex (MHC) haplotypes are associated with several autoimmune diseases, and these appear to depend on ancestry. Objective. To evaluate the association of extended MHC gene frequencies, ancestry, and acute rejection. Material and methods. 127 living kidney transplant recipients who underwent kidney transplantation in Mexico City between January 2004 and October 2007 with follow up until October 2008. The primary outcome was biopsy proven acute rejection. Ancestry was considered as either Amerindian or admixtures with Caucasian, African or Oriental genes. Allele and haplotype frequencies were estimated for HLA A, B and DR loci. Hardy Weinberg (HW) and delta values were analyzed to test for linkage disequilibrium (LD).© Revista de Investigación Clínica
Scopus© Citations 2 36 2
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Acute kidney injury in cardiac surgery
(2013)
Moguel-González, Bernardo
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Wasung-de-Lay, Michael
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Tella-Vega, Pamela
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Riquelme-Mc-Loughlin, Constanza
;
Madero, Magdalena
Introduction. Acute kidney injury (AKI) associated with cardiac surgery is a common postoperative complication that increases the morbidity and mortality substantially. However, there is limited information of AKI after cardiac surgery in our institution. Material and methods. We conducted a prospective, observational, and longitudinal analysis of adult patients that underwent to cardiac surgery requiring cardiopulmonary bypass and aortic cross clamp. Patients with preoperative chronic renal insufficiency that were on dialysis, with AKI detected up to 24 h before the procedure, or that received contrast agents 72 h before surgery were excluded. AKI was defined by the AKIN classification. Patients were followed up to 7 days after surgery or before if discharged from the intensive care unit. We analyzed age, sex, body mass index (BMI), co-morbilities, previous cardiac surgery, left ventricular ejection fraction, New York Heart Association class, type of procedure, cardiopulmonary bypass time, cross clamp time and bleeding.
11 1
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Decreased kidney function and agricultural work: a cross-sectional study in middle-aged adults from Tierra Blanca, Mexico
(2020)
Aguilar-Ramirez, Diego
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Raña-Custodio, Alejandro
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Olvera, Nadia
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Rubilar, Ximena
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Escobar, Alejandro
Background: We aimed to determine the prevalence of decreased kidney function in a potential chronic kidney disease (KD) of unknown aetiology hotspot in Mexico, assess its distribution across occupations and examine the associated risk factors. Methods: A cross-sectional study collected sociodemographic, occupational, medical and biometric data from 616 men and women aged 20-60 years who were residents of three communities within the Tierra Blanca region in Mexico. Kidney function was assessed by standardized serum creatinine and estimated glomerular filtration rate (eGFR) and semi-quantitative albumin-to-creatinine ratio (ACR). To examine the distribution of decreased kidney function within the population, age- and sex-adjusted prevalence of low eGFR (≤60 mL/min/1.73 m2) was estimated for all participants and across occupations. Multivariable logistic regression was used to assess the association of occupation with having low eGFR.
Scopus© Citations 16 22 1

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