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Author: search.filters.author.Martínez-Madrigal, Fernando

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    Meduloepitelioma pigmentado maligno intraocular. Presentación de dos casos
    (2009)
    Soria-Céspedes, Danny
    ;
    Martínez-Madrigal, Fernando
    ;
    Méndez-Sashida, Pedro
    ;
    Intraocular medulloepithelioma is a rare embryonal tumour that occurs most often in the ciliary body, but may also arise from the iris, retina or optic nerve. We present two cases of pigmented malignant intraocular medulloepithelioma; one teratoid (with hyaline cartilage as a heterologous element), and one non-teratoid. Histochemistry showed the neoplastic cells synthesizing both an acidic substance that stained positive with alcian blue and melanin pigment positive for Fontana- Masson stain. Immunohistochemistry showed positive staining for markers of several lines of differentiation including neuroepithelial (S100 protein, synaptophysin), glial (GFAP), mesenchymal/muscle (vimentin, desmin), epithelial (cytokeratin AE1/3, EMA) and melanocytic (HMB-45, Melan-A). Intraocular medulloepithelioma is composed of multipotential cells capable of polyimmunophenotypic expression. © Revista Española de Patología
    Scopus© Citations 2  37  2
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    Granular cell tumor (Abrikossoff tumor) of the thyroid gland
    (2009)
    Espinosa-de-Los-Monteros-Franco, Vladimir A.
    ;
    Martínez-Madrigal, Fernando
    ;
    Only 4 cases of granular cell tumor of the thyroid have been previously reported in the English literature. We report herein the fifth case of this uncommon neoplasm and the first one affecting a male patient. The tumor was well circumscribed and located to the left thyroid lobe, near the isthmus. Histologically, the tumor was composed of large, rounded, granular eosinophilic cells that were immunohistochemically positive for S-100, calretinin, and PGP9.5 and negative for cytokeratin AE1-3, TTF-1, and thyroglobulin. ©Annals of Diagnostic Pathology
    Scopus© Citations 14  10  2