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Permanent URI for this communityhttps://scripta.up.edu.mx/handle/20.500.12552/1

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Social Positions in the Liber de Regno Sicilie : Using Structural Equivalences in an Attempt to Analyze the Narrative of Pseudo-Falcandus
(Central European University - Budapest Campus, 2014)
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Small Doses of Entrepreneurial Content (SDEC) to Foster Entrepreneurial Competencies in Biotechnology Engineering
(IEEE, 2025-04-22)
Silveyra-León, Geraldina
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Tlacuilo-Parra, Luz Yenira
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Perfecto-Avalos, Yocanxóchitl
Entrepreneurial universities emphasize teaching, research, and community outreach, with entrepreneurial education playing a vital role in fostering an entrepreneurial culture and achieving social and economic impact. While entrepreneurial education is well-established in business programs, its integration into non-business disciplines, such as engineering, presents unique challenges, including aligning entrepreneurial content with technical curricula and measuring outcomes effectively. This study examines the impact of delivering Small Doses of Entrepreneurial Content (SDEC) on senior biotechnology students' key entrepreneurial competencies-decision-making, resilience, and opportunity recognition. The SDEC was integrated into a course through a “Learning Kit” comprising lectures, workshops, entrepreneurial talks, and project evaluations. Using a pre-and post-intervention design with validated scales and statistical analyses, the study revealed significant gains in specific decision-making and opportunity recognition skills, particularly among students with prior entrepreneurial exposure. This research contributes to the literature by addressing the challenges of designing entrepreneurial education in non-business disciplines and offering a scalable, transversal approach that complements technical curricula. The findings underscore the potential for embedding entrepreneurial education across diverse disciplines and provide a practical reference for educators seeking to implement such interventions effectively.
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A Stemma of Sigurgarðs saga frækna, and a Case Study of Saga-Anthologization
(Zenodo, 2026)
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Mcdonald, Sheryl
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Hall, Alaric
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Parsons Katelin Marit
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Simpson, Ian
This article publishes the first stemma of the manuscripts of the fifteenth-century Icelandic romance Sigurgarðs saga frækna, taking in 58 of the 61 known witnesses. It capitalizes on digitally-native publication to publish all underlying data, presenting a fully open-data approach to stemmatics. The article shows how the post-medieval transmission of the saga supports previous claims about how Icelandic sagas in this genre circulated but also takes manuscripts containing Sigurgarðs saga frækna produced in the seventeenth to nineteenth centuries in the Dalir region of Iceland as a case study for a methodologically novel investigation of how scribes went about anthologization. Refining previous work on the manuscript filiations of Ambrósíus saga og Rósamundu, Sigurðar saga turnara, Hálfdanar saga Eysteinssonar, Nítíða saga, and Konráðs saga keisarasonar, and making the first outline of a stemma of Nikulás saga leikara, the study gives our first systematic insight into how the scribes of the eighteenth-century manuscript Rask 32 assembled their anthology, and how their work influenced subsequent anthologies that drew material from that manuscript.
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Social determinants of health and disparities in cancer care for patients with metastatic breast cancer in Mexico.
(American Society of Clinical Oncology (ASCO), 2025)
Chavarri Guerra, Yanin
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Verduzco-Aguirre, Haydee Cristina
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Esparza-Orozco, Maria Fernanda
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Ramos Lopez, Wendy Alicia
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Alvarado, Montserrath
Background: Patients diagnosed with metastatic breast cancer (MBC) in low- and middle-income countries (LMICs) face poorer outcomes than their counterparts in high-income countries. Social determinants of health (SDH)—including housing, food security, employment, and education—have been increasingly recognized as critical non-medical factors influencing access to care and cancer-related outcomes. We aimed to describe SDH among Mexican patients with MBC and examine their association with treatment adherence, receipt of standard therapy, and survival. Methods: This was a prospective multicenter cohort study including patients from three public cancer centers in Mexico City. Eligible participants were adults with MBC receiving first- or second-line systemic therapy. A trained patient navigator conducted structured interviews at baseline and every three months over one year using validated questionnaires (SDH needs, SEAMS, FACT-G, and BPI). Treatments were categorized as standard or non-standard based on NCCN guidelines. Associations between SDH and clinical outcomes were explored using chi-square tests. Linear mixed models were used to assess longitudinal changes in health-related quality of life. Survival was estimated using the Kaplan-Meier method and compared with the log-rank test. Results: A total of 324 patients were included (mean age 58.1 years; 99.7% female). At baseline, 92% reported at least one SDH-related need, most commonly employment (77.5%), housing (55.2%), and food (45.7%). The mean number of SDH needs at baseline was 3.1±1.8, remaining consistent across timepoints. Receipt of standard treatment was lower among those with needs in utilities (47.6% vs. 69.1%, p= 0.001) and education (58.0% vs. 69.0%, p= 0.046). Median SEAMS scores improved slightly over time (35 to 37). Median follow-up was 12.1 months (95% CI, 12.05-12.15). One-year overall survival was 85.0% (95% CI, 81.0–89.0), with no differences based on presence (p = 0.61) or number of SDH needs (p = 0.51) at baseline. The presence of any SDH need was significantly associated with FACT-G scores (p = 0.002) throughout the follow-up period. FACT-G scores were consistently lower in patients with any SDH need, and no significant interaction was observed between time and presence of any SDH need (p = 0.481). Conclusions: SDH needs were highly prevalent and persistent among patients with MBC in Mexico and were associated with lower likelihood of receiving guideline-concordant care and lower quality of life. Addressing these social barriers through targeted interventions may be critical to improving treatment equity and clinical outcomes in LMIC settings. ©The authors ©American Society of Clinical Oncology.
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Exploring Physical and Psychological Child Well-being Indicators in Mexican Children and Adolescents Placed in Residential Care
(Springer Science and Business Media LLC, 2026)
Castaños Cervantes, Susana
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Ojeda-Núñez, Jose Anibal
Mexico currently lacks comprehensive and systematic data on the well-being of children and adolescents in residential care, limiting the formulation of effective child welfare policies. As the first qualitative study of its kind in the country, this research explored indicators of physical and psychological well-being among a purposive sample of 197 children and adolescents living in facilities administered by the National System for the Comprehensive Development of the Family (SNDIF). Using qualitative content analysis of institutional case files, supported by descriptive statistical summaries, the study identified recurring patterns and tendencies related to the physical and psychological conditions of this population. The findings suggest that documented levels of well-being tend to fall below desired standards and that institutional responses may only partially align with the comprehensive protection principles established in Mexican child welfare legislation. By generating qualitative, document-based evidence on children and adolescents in SNDIF facilities, this study contributes to the limited empirical base on institutional care in Mexico. The results underscore the importance of strengthening professional practices, staff training, and intersectoral coordination to better support the holistic development and well-being of children in residential care across Latin American contexts. ©The authors ©Springer.
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La regulación de la eutanasia en Uruguay: examen crítico de la Ley núm. 20.431
(Universidad Nacional Autónoma de México, Instituto de Investigaciones Jurídicas, 2026)
Este artículo analiza la Ley núm. 20.431 de Uruguay, primera legislación en América Latina que regula de manera expresa la eutanasia mediante un marco normativo. La ley se estructura en torno al reconocimiento de la autonomía personal como fundamento del proceso de morir. Sin embargo, desde una perspectiva constitucional y bioética, el estudio identifica tensiones relevantes en el diseño normativo. Se sostiene que la autodeterminación del paciente queda sujeta a mecanismos de validación institucional que la transforman en una autonomía jurídicamente condicionada. Asimismo, la definición legal de eutanasia, como un procedimiento realizado por un médico o por su orden, plantea problemas éticos y jurídicos, al desplazar la ejecución material a terceros. Finalmente, se argumenta que estas ambigüedades normativas inciden en los principios constitucionales de legalidad, seguridad jurídica y el deber estatal de protección de las personas en situación de vulnerabilidad. ©La autora © Universidad Nacional Autónoma de México, Instituto de Investigaciones Jurídicas.
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Computational Identification of Potential Novel Allosteric IHF Inhibitors Using QSAR Modeling to Inhibit Plasmid-Mediated Antibiotic Resistance
(MDPI AG, 2026)
Saurith-Coronell, Oscar
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Sierra-Hernandez, Olimpo
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Rodríguez-Macías, Juan David
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Mora, José R.
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Perez-Perez, Noel
The rapid spread of antibiotic resistance through plasmid-mediated conjugation remains a primary global health concern. Despite its critical role in horizontal gene transfer, no approved drugs currently target this process, leaving a critical therapeutic gap. Integration Host Factor (IHF), a DNA-binding protein essential for plasmid replication and mobilization, emerges as a promising yet underexplored target for anti-conjugation strategies. This work aimed to develop a predictive computational model and identify small molecules that disrupt IHF function, thereby reducing plasmid transfer and limiting resistance gene dissemination. A curated dataset of 65 compounds with reported anti-plasmid activity was analyzed using a 3D-QSAR model based on algebraic descriptors computed with QuBiLS-MIDAS. The model was validated through leave-one-out cross-validation (Q2 = 0.82), Tropsha’s criteria, and Y-scrambling. Representative compounds were selected via pharmacophore clustering and evaluated through molecular docking at both the DNA-binding site and a predicted allosteric pocket of IHF. The most promising complexes underwent 200 ns molecular dynamics simulations to assess stability and interaction patterns. The QSAR model demonstrated strong predictive performance (R2 = 0.90). Docking simulations revealed more favorable binding energies at the allosteric site (up to −12.15 kcal/mol) compared to the DNA-binding site. Molecular dynamics confirmed the stability of these interactions, with allosteric complexes showing lower RMSD fluctuations and consistent binding energy profiles. Dynamic cross-correlation analysis revealed that allosteric ligand binding induces conformational changes in key catalytic residues, including Pro65, Pro61, and Leu66. These alterations may compromise DNA recognition and disrupt the initiation of replication. To our knowledge, this is the first computational study proposing allosteric inhibition of IHF as an anti-conjugation strategy. These findings provide a foundation for experimental validation and the development of novel agents to prevent horizontal gene transfer, offering a promising approach to restoring antibiotic efficacy against multidrug-resistant pathogens. ©The authors ©MDPI.
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Intervention Practices for Promoting Well-Being and Cognitive Development in Hospitalized Children: A Scoping Review
(MDPI AG, 2026-03-10)
Castro-Trigo, Sofía
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Hagen, Alexa von
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Alonso-Stuyck, Paloma
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Miquel, Pau
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A Rapid Single-Phase Blackout Detection Algorithm Based on Clarke–Park Transformations
(MDPI AG, 2026-01-19)
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Valdez-Resendiz, Jesus E.
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Posada, Johnny
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A Partial Power Processing SEPIC Converter for Photovoltaic Applications
(MDPI AG, 2026-03-16)
Rebullosa-Castillo, Josué Francisco
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García-Vite, Pedro Martín
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Contreras-Alvarez, Carolina
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Chavez-Muro, Jose de Jesus
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This paper presents the analysis, design, and experimental validation of a Partial Power Processing (PPP) Single-Ended Primary Inductor Converter (SEPIC) for photovoltaic (PV) applications. The proposed topology limits the fraction of processed power through the active switching stage, thereby reducing MOSFET RMS current and associated conduction losses and improving overall conversion efficiency. A complete analytical framework is developed, including steady-state modeling, state-space formulation, and small-signal analysis. The theoretical results are validated through MATLAB/Simulink simulations and laboratory-scale experimental tests under multiple loading conditions. Comparative analysis against a conventional Full Power Processing (FPP) SEPIC converter demonstrates that the proposed PPP configuration achieves efficiencies up to 95% in simulation and up to 93% experimentally, compared to 87% for the FPP counterpart under identical nominal conditions (𝑉in =18 V, 𝑓s =70 kHz). Additionally, the PPP approach reduces the MOSFET RMS current by more than 50%, which directly translates into lower conduction losses and reduced device power dissipation. The results confirm that the proposed PPP-SEPIC converter constitutes a technically viable and energy-efficient solution for photovoltaic DC–DC power conversion systems.

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