Control of Coupled Circadian Oscillators

Circadian rhythms are endogenous rhythms in physiology or behavior with a cycle length near 24 hours. Circadian rhythms are relevant for many key physiological functions. The periodic light-dark cycle is the dominant environmental synchronizer used to entrain a population of circadian oscillators. In this work we introduce a control approach for both suppression and synchronization of coupled circadian oscillators. The control scheme is based on a modeling error compensation approach. Numerical simulations shows the effectivity of the feedback control law for suppression and synchronization of an array of coupled circadian oscillators via a light-sensitive parameter.