Different evolutionary pathway of B*570101 and B*5801 ( B17 group) alleles based in intron sequences

Martínez-Laso, Jorge; Moscoso, Juan; Zamora, Jorge; Martin-Villa, Manuel; Lowy, Ernesto; Vargas Alarcón, Gilberto; Serrano-Vela, Juan Ignacio; Gomez-Casado, Eduardo; Arnaiz-Villena, Antonio

doi:10.1007/s00251-004-0646-5

Different evolutionary pathway of B570101 and B5801 ( B17 group) alleles based in intron sequences

Journal

Immunogenetics

ISSN

0093-7711

1432-1211

Date Issued

2004

Author(s)

Martínez-Laso, Jorge

Moscoso, Juan

Zamora, Jorge

Martin-Villa, Manuel

Lowy, Ernesto

Vargas Alarcón, Gilberto

Facultad de Ciencias de la Salud - CampCM

Serrano-Vela, Juan Ignacio

Gomez-Casado, Eduardo

Arnaiz-Villena, Antonio

Type

text::journal::journal article

DOI

10.1007/s00251-004-0646-5

URL

https://scripta.up.edu.mx/handle/20.500.12552/2513

Abstract

Two theories about MHC allele generation have been put forward: (1) point mutation diversification and/or (2) gene conversion events. A model supporting the existence of both of these mechanisms is shown in this paper; the possible evolution of the HLA-B*570101 and HLA-B*5801 alleles (which belong to the HLA-B17 serology group) is studied. The hypothesis favoured is that gene conversion events have originated these alleles, because intron sequences are also analysed. Evolution by point mutation should only be accepted if flanking introns have also been sequenced. ©Immunogenetics