Collagen-PVP, a collagen synthesis modulator, decreases intraperitoneal adhesions
Journal
Journal of Surgical Research
ISSN
0022-4804
Date Issued
2003
Author(s)
Cervantes-Sánchez, Carlos R.
Olaya, Enrique
Testas, Manuel
Garcia-López, Norberto
Coste, Gabriel
Luna, Adrián
Krötzsch, Fernando Edgar
Type
text::journal::journal article
Abstract
Background. Adhesion formation in the peritoneal cavity is the most common cause of intestinal obstruction and secondary female infertility. A great effort has been dedicated to reduce adhesion formation because of the associated morbidity and its complications.
Materials and methods. This study was designed as a before-after comparative trial and included 14 rabbits, with a weight between 300 and 500 g. All rabbits were appendectomized and 1 month later laparotomized to assess adhesion formation. Rabbits were randomized into two groups, Group I (control group), with no intervention, and Group II (experimental group), treated with an intraperitoneal sponge of collagen-polyvinylpyrrolidone (Clg-PVP). The laparotomy procedure was repeated 1 month later for a new assessment of adhesion formation and histological evaluation by H-E and Masson staining.
Materials and methods. This study was designed as a before-after comparative trial and included 14 rabbits, with a weight between 300 and 500 g. All rabbits were appendectomized and 1 month later laparotomized to assess adhesion formation. Rabbits were randomized into two groups, Group I (control group), with no intervention, and Group II (experimental group), treated with an intraperitoneal sponge of collagen-polyvinylpyrrolidone (Clg-PVP). The laparotomy procedure was repeated 1 month later for a new assessment of adhesion formation and histological evaluation by H-E and Masson staining.