Risk factors associated with thyroid nodular disease in acromegalic patients: A case-cohort study in a tertiary center
Journal
Growth Hormone & IGF Research
ISSN
1096-6374
Date Issued
2021
Author(s)
Vargas-Ortega, Guadalupe
Romero-Gameros, Carlos Alfonso
Balcázar-Hernández, Lourdes
Sosa-Eroza, Ernesto
Mercado, Moises
Espinosa de los Monteros-Sánchez, Ana L.
Pérez-Aguilar, Barbara
Paredes-Manjarrez, Carlos
Reyes-Olhagaray, Fernando Bernardo
Serrano-Ramírez, Diana Laura
Martínez-De la Cruz, Erick Vladimir
González-Virla, Baldomero
Type
text::journal::journal article
Abstract
Introduction: Goiter is very common in patients with acromegaly; its development is correlated to the duration of the disease. Thyroid cells express the IGF-1 receptor and the TSH/IGF-1 interaction has been demonstrated to have a synergistic effect in thyroid cell growth. There is a correlation between IGF-1 levels and the thyroid volume of patients with acromegaly. The aim of this study was to evaluate, in a retrospective case-cohort study of patients with acromegaly, the associated risk factors for thyroid nodules disease in this population. Methods: This was a case-cohort study matched by age, gender, and growth hormone at diagnosis. Cases consisted of acromegalic patients that developed thyroid nodules during the follow up, and controls consisted in acromegalic patients without thyroid nodules. A Cox proportional hazard estimation was carried out for measure the associated risk factors for thyroid nodules disease in acromegalic patients. A nodular thyroid disease-free survival analysis was estimated using the Kaplan-Meier analysis. © Growth Hormone & IGF Research