Daprodustat for the Treatment of Anemia in Patients Not Undergoing Dialysis

Singh, Ajay K.; Carroll, Kevin; McMurray, John J. V.; Solomon, Scott; Jha, Vivekanand; Johansen, Kirsten L.; Lopes, Renato D.; Macdougall, Iain C.; Obrador, Gregorio; Waikar, Sushrut S.; Wanner, Christoph; Wheeler, David C.; Więcek, Andrzej; Blackorby, Allison; Cizman, Borut; Cobitz, Alexander R.; Davies, Rich; DiMino, Tara L.; Kler, Lata; Meadowcroft, Amy M.

doi:10.1056/NEJMoa2113380

Daprodustat for the Treatment of Anemia in Patients Not Undergoing Dialysis

Journal

New England Journal of Medicine

ISSN

0028-4793

1533-4406

Date Issued

2021

Author(s)

Singh, Ajay K.

Carroll, Kevin

McMurray, John J. V.

Solomon, Scott

Jha, Vivekanand

Johansen, Kirsten L.

Lopes, Renato D.

Macdougall, Iain C.

Obrador, Gregorio

Facultad de Ciencias de la Salud - CampCM

Waikar, Sushrut S.

Wanner, Christoph

Wheeler, David C.

Więcek, Andrzej

Blackorby, Allison

Cizman, Borut

Cobitz, Alexander R.

Davies, Rich

DiMino, Tara L.

Kler, Lata

Meadowcroft, Amy M.

Taft, Lin

Perkovic, Vlado

Type

text::journal::journal article

DOI

10.1056/NEJMoa2113380

URL

https://scripta.up.edu.mx/handle/20.500.12552/2169

Abstract

Background: Daprodustat is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor. In patients with chronic kidney disease (CKD) who are not undergoing dialysis, the efficacy and safety of daprodustat, as compared with the conventional erythropoiesis-stimulating agent darbepoetin alfa, are unknown. Methods: In this randomized, open-label, phase 3 trial with blinded adjudication of cardiovascular outcomes, we compared daprodustat with darbepoetin alfa for the treatment of anemia in patients with CKD who were not undergoing dialysis. The primary outcomes were the mean change in the hemoglobin level from baseline to weeks 28 through 52 and the first occurrence of a major adverse cardiovascular event (MACE; a composite of death from any cause, nonfatal myocardial infarction, or nonfatal stroke). Copyright © 2021 Massachusetts Medical Society.