Risk Factors Associated with Mortality among Patients with COVID-19: Analysis of a Cohort of 1213 Patients in a Tertiary Healthcare Center
Journal
Journal of Clinical Medicine
ISSN
2077-0383
Date Issued
2022
Author(s)
Romero-Gameros, Carlos Alfonso
Vargas-Ortega, Guadalupe
Cuevas-García, Carlos Fredy
Colín-Martínez, Tania
Sánchez-Hurtado, Luis Alejandro
Balcázar-Hernández, Lourdes Josefina
De la Cruz-Rodríguez, Iván Emilio
Pérez-Dionisio, Enid Karina
Retana-Torres, Perla Michelle
García-Montesinos, Elsy Sarahí
López-Moreno, Mayra Alejandra
Intriago-Alor, Marielle
Waizel-Haiat, Salomón
González-Virla, Baldomero
Type
text::journal::journal article
Abstract
The presence of cardio-metabolic and respiratory comorbidities, immunosuppression, and chronic kidney disease have been associated with an increase in mortality from COVID-19. The objective of this study is to establish the risk factors associated with 30-day mortality in a cohort of hospitalized patients with COVID-19. This paper conducts a retrospective and analytical study of patients hospitalized for COVID-19 in a tertiary care center. A Cox proportional hazard analysis was performed to estimate the association of comorbidities with 30-day mortality. A total of 1215 patients with a median age of 59 years were included. In the adjusted Cox proportional hazards regression model, hypothyroidism, D-dimer ≥ 0.8 μg/mL, LHD ≥ 430 IU/L, CRP ≥ 4.83 ng/mL, and triglycerides ≥ 214 mg/dL were associated with an increased risk of death. The presence of a history of hypothyroidism and biomarkers (D-dimer, lactic dehydrogenase, CRP, and triglycerides) were associated with an increase in mortality in the studied cohort. © Journal of Clinical Medicine