Does DOTS work in populations with drug-resistant tuberculosis?

DeRiemer, Kathryn; García-García, Lourdes; Bobadilla-del-Valle, Miriam; Palacios-Martínez, Manuel; Martínez-Gamboa, Areli; Small, Peter M.; Sifuentes-Osornio, José

doi:10.1016/S0140-6736(05)74812-1

Does DOTS work in populations with drug-resistant tuberculosis?

Journal

The Lancet

ISSN

0140-6736

Date Issued

2005

Author(s)

DeRiemer, Kathryn

García-García, Lourdes

Bobadilla-del-Valle, Miriam

Palacios-Martínez, Manuel

Martínez-Gamboa, Areli

Small, Peter M.

Sifuentes-Osornio, José

Type

text::journal::journal article

DOI

10.1016/S0140-6736(05)74812-1

URL

https://scripta.up.edu.mx/handle/20.500.12552/2502

Abstract

Background: Directly observed therapy (DOTS) is the main strategy for prevention and control of tuberculosis worldwide. However, its effect on tuberculosis transmission in populations with moderate rates of drug-resistant disease is not known. Methods: This population-based prospective study in southern Mexico between March, 1995, and February, 2000, was based on passive case finding and detection of acid-fast bacilli in sputum samples to diagnose pulmonary tuberculosis. We also used cultures, drug-susceptibility testing, bacterial genotyping, and monitoring of treatment outcomes. © The Lancet