Extrastriatal degeneration correlates with deficits in the motor domain subscales of the UHDRS

Gálvez , Víctor; Ramírez-García, Gabriel; Hernandez-Castillo, Carlos R.; Bayliss, Leo; Díaz, Rosalinda; Lopez-Titla, María Margarita; Campos-Romo, Aurelio; Fernandez-Ruiz, Juan

doi:10.1016/j.jns.2017.11.040

Extrastriatal degeneration correlates with deficits in the motor domain subscales of the UHDRS

Journal

Journal of the Neurological Sciences

ISSN

0022-510X

Date Issued

2018

Author(s)

Gálvez , Víctor

Facultad de Ciencias de la Salud - CampCM

Ramírez-García, Gabriel

Hernandez-Castillo, Carlos R.

Bayliss, Leo

Díaz, Rosalinda

Lopez-Titla, María Margarita

Campos-Romo, Aurelio

Fernandez-Ruiz, Juan

Type

text::journal::journal article

DOI

10.1016/j.jns.2017.11.040

URL

https://scripta.up.edu.mx/handle/20.500.12552/2251

Abstract

Introduction: Striatal degeneration has significant behavioral effects in patients with Huntington's disease (HD). However, there is scant evidence of the possible contribution of extrastriatal regions to the motor alterations assessed within the different domains of the Unified Huntington's Disease Rating Scale (UHDRS). Objective: Analyze if extrastriatal grey matter decrease in patients with HD correlates with motor performance assessed with the UHDRS and its different domains. Method: Twenty-two molecular diagnosed patients with incipient HD, and twenty-two control participants matched for sex and age participated in this study. Voxel-based morphometry (VBM) analyses were done to identify grey matter decrease in the HD patients, and its relationship with the motor deterioration measured with the UHDRS motor scale. To further explore this relationship, a principal component analysis (PCA) was done on the UHDRS domains scores. Then the average of each component was used as a covariate in a VBM analysis. Finally, individual sub-scores from each domain were also tested for correlations with the VBM results.