Mobilization Success and Bariers for Autologous Hematopoietic Stem Cell Transplantation in a Constrained-Resource Nation

Acosta-Medina, Aldo A.; Arias-Espinosa, Luis; Villaseñor-Echavarri, Rodrigo; Chouciño, Pedro; Mayo Maldonado, Jonathan; Armillas-Canseco, Flor M.; Barrera-Lumbreras, Georgina; Bourlón de los Ríos, Christianne

doi:10.1016/j.bbmt.2019.12.554

Mobilization Success and Bariers for Autologous Hematopoietic Stem Cell Transplantation in a Constrained-Resource Nation

Journal

Biology of Blood and Marrow Transplantation

ISSN

1083-8791

Date Issued

2020

Author(s)

Acosta-Medina, Aldo A.

Arias-Espinosa, Luis

Facultad de Ciencias de la Salud - CampCM

Villaseñor-Echavarri, Rodrigo

Facultad de Ciencias de la Salud - CampCM

Chouciño, Pedro

Facultad de Ciencias de la Salud - CampCM

Mayo Maldonado, Jonathan

Facultad de Ciencias de la Salud - CampCM

Armillas-Canseco, Flor M.

Barrera-Lumbreras, Georgina

Bourlón de los Ríos, Christianne

Type

text::journal::journal article

DOI

10.1016/j.bbmt.2019.12.554

URL

https://scripta.up.edu.mx/handle/20.500.12552/2206

Abstract

Introduction: Autologous stem cell transplantation (ASCT) is a well-established therapy for various hematologic and solid malignancies. Optimal mobilization and harvest of peripheral blood-stem cells (PBSC) is crucial. A failed mobilization attempt (MA) can preclude transplantation in up to 40% of cases, however, novel agents have increased success rates. The aim of our study was to evaluate factors impacting MA failure and remobilization efficacy in a resource-constrained setting. Methods: Retrospective single-center study including patients with at least one MA of PBSC for ASCT between June 2010 to June 2019.