Gálvez , Víctor

Main Affiliation

Facultad de Ciencias de la Salud - CampCM

Preferred name

Gálvez , Víctor

Official Name

Gálvez Zúñiga, Víctor Hugo

ORCID

0000-0002-6075-9620

Researcher ID

AFR-5821-2022

Scopus Author ID

55813224800

Now showing 1 - 10 of 14

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Tobacco Use Among Adolescents: National Survey vs. Private High Schools in Mexico City
(Instituto Nacional de Salud Publica, 2026)
González-López, Ximena
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Vázquez-Moreno, Dafne
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Gálvez , Víctor
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Azcárraga Quiza, Mariana Estefanía
Dear editor: Tobacco consumption re-mains a major public health challenge, raising concerns along with the in-creasing popularity of e-cigarettes. In Mexico, data on this issue is generally derived from the overall population, which may conceal at risk subgroups. ©The authors ©Instituto Nacional de Salud Pública.
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Theory of mind impairment in Huntington's disease patients and their relatives
(2019)
Bayliss, Leo
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Gálvez , Víctor
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Ochoa Diaz, Adriana
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Chávez-Oliveros, Mireya
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Rodríguez-Agudelo, Yaneth
Huntington disease (HD) is an autosomal dominant genetic disorder characterized by movement disorders, cognitive impairment, and psychiatric symptoms. Relatives of HD patients experience a great burden as the latter suffer from altered social conduct and deterioration of interpersonal relationships. Theory of mind (ToM) is the ability to attribute mental states (to oneself and others). Deficits in ToM are thought to have a role in the changes in empathy and interpersonal difficulties that HD patients face. METHODS We conducted a cross sectional study to compare ToM task scores of patients with mild to moderate HD, their relatives (spouse or at-risk first-degree relative with a negative gene test) and controls.Individuals with dementia or depression were excluded. The ToM test battery included Spanish versions of the Reading Mind in the Eyes Test (RMET), Happé's Strange Stories (Social and Physical Stories subtests) and the Hinting Task. RESULTS The series comprised 12 HD patients, 12 relatives and 12 controls. The HD patients showed lower affective ToM scores than controls (RMET 19 [3.5] vs 23.9 [2.7], p = 0.016). Cognitive ToM tasks scores were lower in HD patients than controls as well (Happé's Social Stories 9 [2.6] vs 13 [1.9], p = 0.001; the Hinting Task 13.6 [3.4] vs 17.5 [4.0], p = 0.009). In the Hinting Task, HD relatives had lower scores in than controls (13 [3.2] vs 17.5 [4.0], p = 0.009) and similar scores to controls in the rest of the battery. CONCLUSION The HD patients with mild to moderate disease severity and their relatives show ToM deficits.
Scopus© Citations 16 13 1
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Montreal Cognitive Assessment (MoCA) performance in Huntington’s disease patients correlates with cortical and caudate atrophy
(2022)
Ramirez-Garcia, Gabriel
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Gálvez , Víctor
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Diaz, Rosalinda
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Campos-Romo, Aurelio
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Fernandez-Ruiz, Juan
Huntington's Disease (HD) is an autosomal neurodegenerative disease characterized by motor, cognitive, and psychiatric symptoms. Cognitive impairment develops gradually in HD patients, progressing later into a severe cognitive dysfunction. The Montreal Cognitive Assessment (MoCA) is a brief screening test commonly employed to detect mild cognitive impairment, which has also been useful to assess cognitive decline in HD patients. However, the relationship between MoCA performance and brain structural integrity in HD patients remains unclear. Therefore, to explore this relationship we analyzed if cortical thinning and subcortical nuclei volume differences correlated with HD patients' MoCA performance. Twenty-two HD patients and twenty-two healthy subjects participated in this study. T1-weighted images were acquired to analyze cortical thickness and subcortical nuclei volumes. Group comparison analysis showed a significantly lower score in the MoCA global performance of HD patients. Also, the MoCA total score correlated with cortical thinning of fronto-parietal and temporo-occipital cortices, as well as with bilateral caudate volume differences in HD patients. These results provide new insights into the effectiveness of using the MoCA test to detect cognitive impairment and the brain atrophy pattern associated with the cognitive status of prodromal/early HD patients.
Scopus© Citations 2 32 2
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Longitudinal atrophy characterization of cortical and subcortical gray matter in Huntington’s disease patients
(2019)
Ramírez‐García, Gabriel
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Gálvez , Víctor
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Diaz, Rosalinda
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Bayliss, Leo
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Fernandez-Ruiz, Juan
Huntington's disease (HD) is an inherited neurodegenerative disease with clinical manifestations that involve motor, cognitive and psychiatric deficits. Cross-sectional magnetic resonance imaging (MRI) studies have described the main cortical and subcortical macrostructural atrophy of HD. However, longitudinal studies characterizing progressive atrophy are lacking. This study aimed to describe the cortical and subcortical gray matter atrophy using complementary volumetric and surface-based MRI analyses in a cohort of seventeen early HD patients in a cross-sectional and longitudinal analysis and to correlate the longitudinal volumetric atrophy with the functional decline using several clinical measures. A group of seventeen healthy individuals was included as controls. After obtaining structural MRIs, volumetric analyses were performed in 36 cortical and 7 subcortical regions of interest per hemisphere and surface-based analyses were performed in the whole cortex, caudate, putamen and thalamus. Cross-sectional cortical surface-based and volumetric analyses showed significant decreases in frontoparietal and temporo-occipital cortices, while subcortical volumetric analysis showed significant decreases in all subcortical structures except the hippocampus. The longitudinal surface-based analysis showed widespread cortical thinning with volumetric decreases in the superior frontal lobe, while a subcortical volumetric decrease occurred in the caudate, putamen and thalamus with shape deformation on the anterior, medial and dorsal side. Functional capacity and motor status decline correlated with caudate progressive atrophy, while cognitive decline correlated with left superior frontal and right paracentral progressive atrophy. These results provide new insights into progressive volumetric and surface-based morphometric atrophy of gray matter in HD.
Scopus© Citations 12 14 2
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Planning deficits in Huntington’s disease: A brain structural correlation by voxel-based morphometry
(2021)
Calderon-Villalon, Jesus
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Ramirez-Garcia, Gabriel
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Fernandez-Ruiz, Juan
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Sangri-Gil, Fernanda
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Campos-Romo, Aurelio
Introduction: Early Huntington’s disease (HD) patients begin to show planning deficits even before motor alterations start to manifest. Generally, planning ability is associated with the functioning of anterior brain areas such as the medial prefrontal cortex. However, early HD neuropathology involves significant atrophy in the occipital and parietal cortex, suggesting that more posterior regions could also be involved in these planning deficits. Objective: To identify brain regions associated with planning deficits in HD patients at an early clinical stage. Materials and methods: Twenty-two HD-subjects genetically confirmed with incipient clinical manifestation and twenty healthy subjects were recruited. All participants underwent MRI T1 image acquisition as well as testing in the Stockings of Cambridge (SOC) task to measure planning ability. First, group comparison of SOC measures were performed. Then, correlation voxel-based morphometry analyses were done between gray matter degeneration and SOC performance in the HD group
Scopus© Citations 3 31 2
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Extrastriatal degeneration correlates with deficits in the motor domain subscales of the UHDRS
(2018)
Gálvez , Víctor
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Ramírez-García, Gabriel
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Hernandez-Castillo, Carlos R.
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Bayliss, Leo
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Díaz, Rosalinda
Introduction: Striatal degeneration has significant behavioral effects in patients with Huntington's disease (HD). However, there is scant evidence of the possible contribution of extrastriatal regions to the motor alterations assessed within the different domains of the Unified Huntington's Disease Rating Scale (UHDRS). Objective: Analyze if extrastriatal grey matter decrease in patients with HD correlates with motor performance assessed with the UHDRS and its different domains. Method: Twenty-two molecular diagnosed patients with incipient HD, and twenty-two control participants matched for sex and age participated in this study. Voxel-based morphometry (VBM) analyses were done to identify grey matter decrease in the HD patients, and its relationship with the motor deterioration measured with the UHDRS motor scale. To further explore this relationship, a principal component analysis (PCA) was done on the UHDRS domains scores. Then the average of each component was used as a covariate in a VBM analysis. Finally, individual sub-scores from each domain were also tested for correlations with the VBM results.
Scopus© Citations 5 5 2
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Influences on the emergence of strategic visuomotor learning mechanisms in school-aged children.
(American Psychological Association (APA), 2025)
Gálvez , Víctor
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Calderón-Villalon Jesús
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Gómez-Moya, Rosinna
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Fernández-Ruiz, Juan
Visuomotor development is based on implicit procedural and explicit strategic learning mechanisms. Given that both of these mechanisms are associated with child maturation, we sought to explore the effect of three related variables on adaptation rates: chronological age, intelligence quotient, and motor skills. In our study, 86 healthy school-aged children (grouped in 6–7, 8–9, and 10–11 years) with no reported visual or developmental disorders participated in a prism-throwing task under two different conditions. In the first condition, we introduced a wedge prism that displaces the visual field laterally. Adapting to this kind of visual perturbation relies mainly on procedural mechanisms. In the second condition, we introduced a dove prism, which reverses the visual field horizontally, allowing us to evaluate explicit strategic learning mechanisms. Most of the children managed to adapt to the use of implicit procedures based on the error feedback, regardless of age. However, older children were able to adopt explicit strategies to counteract the optical disturbance generated by the dove prism in greater proportions, irrespective of motor ability scores or intelligence quotient. Our results suggest that adopting strategic mechanisms depends more on chronological development than on intelligence or motor skills. In contrast, implicit error-based visuomotor learning consolidates from an early age. (PsycInfo Database Record (c) 2025 APA, all rights reserved) ©The authors
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What Does it Mean to Measure Mind Perception toward Robots? A Critical Review of the Main Self-Report Instruments
(Springer Nature, 2024)
Gálvez , Víctor
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Hanono, Esther
Although most studies that seek to measure participants’ judgments and attitudes regarding humanoid robots’ possessing (or appearing to possess) a mind or mental capacities have been based on verbal measures, there is yet no standard psychometric instrument for this end. Using a COSMIN approach, this critical review seeks to summarize the most valid and reliable self-report instruments that aim to measure mental state attribution to humanoid robots. 501 papers were reviewed, but only 11 were included, finding that: (1) The instruments do not usually measure mental state attribution toward robots as an exclusive phenomenon but as a factor associated with the tendency to anthropomorphize non-human entities; (2) There is a lack of consensus regarding a definition of mental state attribution and the psychometric dimensions that underlie it; (3) The tendency to anthropomorphize does not by itself imply the attribution of mind to robots. In our discussion, we delve into the general problem of mind perception/attribution and speculate on the possible theoretical basis for a multifactorial model for measuring mind perception as part of a broader phenomenon we term “psycheidolia.” © 2024 Springer Nature
Scopus© Citations 1 15 1
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Resting-state networks and their relationship with MoCA performance in PD patients
(Springer, 2024-01-01)
Gálvez , Víctor
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Romero-Rebollar, César
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Estudillo-Guerra, M. Anayali
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Fernandez-Ruiz, Juan
Although mild cognitive impairment is a common non-motor symptom experienced by individuals with Parkinson’s Disease, the changes in intrinsic resting-state networks associated with its onset in Parkinson’s remain underexamined. To address the issue, our study sought to examine resting-state network alterations and their association with total performance in the Montreal Cognitive Assessment and its cognitive domains in Parkinson’s by means of functional magnetic resonance imaging of 29 Parkinson’s patients with normal cognition, 25 Parkinson’s patients with mild cognitive impairment, and 13 healthy controls. To contrast the Parkinson’s groups with each other and the controls, the images were used to estimate the Z-score coefficient between the regions of interest from the default mode network, the salience network and the central executive network. Our first finding was that default mode and salience network connectivity decreased significantly in Parkinson’s patients regardless of their cognitive status. Additionally, default mode network nodes had a negative and salience network nodes a positive correlation with the global assessment in Parkinson’s with normal cognition; this inverse relationship of both networks to total score was not found in the group with cognitive impairment. Finally, a positive correlation was found between executive scores and anterior and posterior cortical network connectivity and, in the group with cognitive impairment, between language scores and salience network connectivity. Our results suggest that specific resting-state networks of Parkinson’s patients with cognitive impairment differ from those of Parkinson’s patients with normal cognition, supporting the evidence that cognitive impairment in Parkinson’s Disease displays a differentiated neurodegenerative pattern. ©Springer
Scopus© Citations 1 42 2
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Is brain perfusion correlated to switching mood states and cognitive impairment in bipolar disorder type I? A longitudinal study using perfusion imaging approach
(2023)
Estudillo-Guerra, Maria Anayali
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Linnman, Clas
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Gálvez , Víctor
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Chapa-Koloffon, Gina
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Pacheco-Barrios, Kevin
Type I Bipolar disorder (BD-I) is a neuropsychiatric disorder characterized by manic or mixed-featured episodes, impaired cognitive functioning, and persistent work and social functioning impairment. This study aimed to investigate within-subject; (i) differences in brain perfusion using Single-photon emission computed tomography (SPECT) between manic and euthymic states in BD-I patients; (ii) explore potential associations between altered brain perfusion and cognitive status; and (iii) examine the relationship between cerebral perfusion and mania symptom ratings. Seventeen adult patients diagnosed with BD-I in a manic episode were recruited, and clinical assessments, cognitive tests, and brain perfusion studies were conducted at baseline (mania state) and a follow-up visit 6 months later. The results showed cognitive impairment during the manic episode, which persisted during the euthymic state at follow-up. However, no significant changes in brain perfusion were observed between the manic and euthymic states. During mania, trends toward decreased perfusion in the left cerebellum and right superior parietal lobule were noted. Additionally, trends indicated a higher perfusion imbalance in the left superior and middle frontal gyrus during mania and the right superior and middle frontal gyrus during euthymia. No significant correlations existed between brain perfusion, mania symptom ratings, and cognitive performance, indicating that symptomatology might represent more than neural hemodynamics. These findings suggest that cognitive impairment may persist in BD-I patients and highlight the need for therapeutic interventions targeting cognitive deficits. More extensive studies with extended follow-up periods are warranted further to investigate brain perfusion and cognitive functioning in BD-I patients.
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Gálvez , Víctor

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