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    Item type:Publication,
    Mental health-related, existential, and biological factors are associated with the desire to hasten death in Mexican cancer patients undergoing palliative care: A single-center study
    (Public Library of Science (PLoS), 2025)
    Rodríguez-Mayoral, Oscar
    ;
    Monreal-Carrillo, Edith
    ;
    Contreras-Yáñez, Irazú
    ;
    Allende-Pérez, Silvia
    ;
    Agazzi, Evandro  
    Introduction: The wish to hasten death (WTHD) is a clinically significant phenomenon that arises from complex suffering. It has been predominantly studied in Caucasian populations, emphasizing the importance of gaining more diverse cultural perspectives. This study explores the factors associated with the WTHD in Mexican cancer patients receiving palliative care from one academic center, with a specific focus on its connection to dignity.“. Patients and methods: The study, a cross-sectional research conducted between October 12, 2023, and August 30, 2024, involved patients with confirmed cancer diagnoses who were attending a palliative care service. Patients had applied the Patient Dignity Inventory (PDI), Schedule of Attitudes Toward Hastened Death (SAHD), Brief Edinburgh Depression Scale (BEDS), EORTC QLQ-C15-PAL to assess health-related quality of life, Karnofsky Performance Status Scale (KPSS) to assess functional capacity, and the Edmonton Symptom Assessment System. A PDI score ≥55 indicated a fractured sense of dignity (DPD), while a SAHD score ≥1 indicated the WTHD. Factors associated with the WTHD were identified using multiple logistic regression analysis. The study was approved by the IRB. Results: The study included 302 primarily middle-aged (54.5 [45–64]) females (225 [74.5%]), with 9 years of education. They reported high severity of well-being (7 [1–7]) and tiredness (3 [0–6]). Their median KPSS score showed independence (80 [70–80]), despite impacts across all EORTC QLQ-C15-PAL dimensions. DPD was noted in 110 patients (36.5%). The most frequent diagnoses were breast cancer (114 [38%]), lung cancer (33 [11%]), and gastrointestinal cancer (28 [9%]). The WTHD was found in 94 patients (31.1%). Factors significantly associated included tiredness score (OR: 1.147, 95% CI: 1.044–1.261, p = 0.004), BEDS score (1.181, 1.085–1.284, p ≤ 0.001) and a DPD (1.979, 1.038–3.772, p = 0.04). Conclusions: The WTHD was found in one out of every three Mexican cancer patients receiving palliative care and was linked to biological-, mental health-, and existential-related factors. ©The authors ©Public Library of Science (PLoS) ©PLOS one
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    Item type:Publication,
    Uso de antidepresivos y bioética
    (Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suarez, 2005)
    Casas-Martínez, María-de-la-Luz  
    La presente reflexión se ha realizado considerando a la bioética como una disciplina promotora del diálogo entre las ciencias bajo el marco de valores morales de la tradición occidental. Se aborda el tema del uso ético de antidepresivos en situaciones existenciales, más que en su uso terapéutico. Los objetivos son la revisión de los siguientes aspectos: a. Una visión antropológica. El hombre como ser carente, b. Los fines de la medicina y el uso de psicofármacos en situaciones limítrofes a la psicopatología. c. La medicalización de la vida humana. Se realiza un análisis de estos aspectos y una propuesta para el manejo de la tristeza en forma no medicamentosa, aceptando los límites humanos al acceso a la felicidad. © La autora © Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suarez © Archivos de Neurociencias.
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