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Tumor fibroso calcificante intestinal: reporte de caso
(Elsevier, 2023)
Cantú-Soriano, Gonzalo Nathaniel
;
Padilla Rodríguez, Álvaro Lezid
Calcifying fibrous tumor (CFT) is a rare benign lesion of mesenchymal origin that may present similar characteristics to other more common tumors. We present the case of a 36-year-old woman with a tumor in the proximal jejunum, initially suspected to be a gastrointestinal stromal tumor (GIST). Surgical resection was performed, revealing a well-demarcated nodule at the anti-mesenteric border with microscopic features typical of a calcifying fibrous tumor. The tumor cells were positive for CD34 and negative for other markers, differentiating it from other neoplasms. Calcifying fibrous tumors can be confused with more common tumors because of its appearance, but an accurate diagnosis supported by immunohistochemistry is essential. Complete surgical excision is usually curative. © 2023 Sociedad Española de Anatomía Patológica. ©Elsevier
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Enfermedad de Kikuchi-Fujimoto (linfadenitis histocítica necrosante). Estudio clinicopatológico e inmunohistoquímico de 14 casos y su diagnóstico diferencial con otras linfadenitis necrosantes reactivas y neoplásicas
(2006-09)
Gutiérrez-Castro, Macrina
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De León-Bojorque, Beatriz
;
Cuesta-Mejías, Teresa
;
Baquera-Heredia, Javier
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Padilla Rodríguez, Álvaro Lezid
Kikuchi-Fujimoto disease also known as histiocytic necrotizing lymphadenopaty (HNL) is a rare entity, originally described in Japanese population, although currently it has been described all over the world. It is more frequent in young women and it is usually located in cervical lymph nodes. We report 14 cases of HNL in Mexican population, their clinicopathological and immunohistochemical study as well as a comparative study with other necrotizing lymphadenopaties due to B or T-cell lymphomas, tuberculosis, Epstein Barr virus infection, and non-specific necrosis. In our study we found that there was more expression of the immunomarkers CD68, MPO, CD123 and antikerat in OSCAR in the cases of HNL in contrast with the lesser or even null expression of the same markers in the necrotized lymph nodes of the comparative study group.
Scopus© Citations 7 9 2
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Carcinoma seroso micropapilar invasor. Informe de un caso bilateral de ovario
(2007-11)
Espinosa de los Monteros Franco, Vladimir Abdel
;
Padilla Rodríguez, Álvaro Lezid
A subject that has been very controvertial in the last few years in the field of the surgical pathology has been the terminology and the concept of borderline serous tumor of ovary (TSL). Recently the term of micropapillary serous carcinoma was introduced (CSMP) to define a subtype of serous tumors that are characterized for a micropapillary grow pattern and that clinically associated with a more aggressive behavior than the classic TSL since they have an increased risk of invasion, recurrence and extraovarian tumor implantation. The majority of these cases are included within the serous bordering tumors of ovary, being the truly invasive tumors even more infrequent and with more aggressive clinical course. We reported the case of a 52 years old woman with bilateral invasive micropapillary serous carcinoma of ovary. ©Ginecología y Obstetricia de México
Scopus© Citations 1 20 1
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Linfoma no Hodgkin anaplásico de células T primario cutáneo rico en neutrófilos y eosinófilos. Estudio inmunohistoquímico de una variante poco frecuente
(2008-01)
Martínez Consuegra, Nayeli
;
Moreno Collado, Clemente
;
;
Padilla Rodríguez, Álvaro Lezid
Anaplastic large cell lymphoma (LACG) is a T-cell lymphoma of pleomorphic CD30-positive cells. According to the expression of the chimeric protein ALK, LACG can be divided into three groups: systemic LACG ALK-positive, systemic LACG ALK-negative, and primary cutaneous LACG ALK-negative. According to the new WHO/EORTC classification, primary cutaneous LACG is included in the cutaneous T-cell lymphoproliferative disorders. We report an infrequent variant of primary cutaneous LACG. A 54-year old man presented with a 5 cm mass in the skin of his right gluteus, which had been present for six months without systemic involvement. Histological findings revealed a diffuse dermal infiltration of large CD3, CD43, CD30-positive, ALK-negative T-cells. Mixed with the neoplastic cells, there was a profuse infiltrate of neutrophils and eosinophils, establishing the diagnosis of neutrophil and eosinophil-rich primary cutaneous LACG. The presence of an increased number of neutrophils and/or eosinophils without necrosis, ulceration or infection is a rare finding in lymphomas, even more rare is the location in the skin of which only 16 cases have been reported in the literature. It is important to be aware of these findings in the differential diagnosis with other reactive or neoplastic entities that are more often accompanied by mixed inflammatory infiltrate, and with a different prognosis and treatment.© Dermatología Revista Mexicana
24 2
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Recurrencia y supervivencia en cáncer de mama temprano en relación a la expresión de Ki-67
(2014)
Gerson-Cwilicha, Raquel
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Alban-de la Torre, Luis Fernando
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Villalobos-Prietoc, Alberto
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Padilla Rodríguez, Álvaro Lezid
;
Serrano-Olvera, Juan Alberto
Background: Breast cancer (BC) is the most common malignant tumor in Mexican women. Ki-67 is a nuclear antigen related to cellular proliferation. Objective: To determine the correlation between Ki-67, recurrence and survival in early BC. Material and methods: Women > 18 years old with invasive BC, clinical stages (CS) I - IIB, ductal OR lobular, underwent surgery and Ki-67 determination were included. We analyzed 4 groups regarding to Ki-67 (MIB1) expression: 1) < 5%, 2) 6%-20%, 3) 21%-50% and 4) > 51%. We performed an inferential statistical analysis to assess differences between groups and univariate and multivariate analysis for detecting association to recurrence and overall survival (OS).
28 2

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