Ortíz Hidalgo, Carlos Federico

Main Affiliation

Facultad de Ciencias de la Salud - CampCM

Preferred name

Official Name

Ortíz Hidalgo, Carlos Federico

ORCID

0000-0002-2456-7402

Researcher ID

DWN-7833-2022

Scopus Author ID

7003618204

Now showing 1 - 10 of 70

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Linfoma no Hodgkin anaplásico de células T primario cutáneo rico en neutrófilos y eosinófilos. Estudio inmunohistoquímico de una variante poco frecuente
(2008-01)
Martínez Consuegra, Nayeli
;
Moreno Collado, Clemente
;
Ortíz Hidalgo, Carlos Federico
;
Padilla Rodríguez, Álvaro Lezid
Anaplastic large cell lymphoma (LACG) is a T-cell lymphoma of pleomorphic CD30-positive cells. According to the expression of the chimeric protein ALK, LACG can be divided into three groups: systemic LACG ALK-positive, systemic LACG ALK-negative, and primary cutaneous LACG ALK-negative. According to the new WHO/EORTC classification, primary cutaneous LACG is included in the cutaneous T-cell lymphoproliferative disorders. We report an infrequent variant of primary cutaneous LACG. A 54-year old man presented with a 5 cm mass in the skin of his right gluteus, which had been present for six months without systemic involvement. Histological findings revealed a diffuse dermal infiltration of large CD3, CD43, CD30-positive, ALK-negative T-cells. Mixed with the neoplastic cells, there was a profuse infiltrate of neutrophils and eosinophils, establishing the diagnosis of neutrophil and eosinophil-rich primary cutaneous LACG. The presence of an increased number of neutrophils and/or eosinophils without necrosis, ulceration or infection is a rare finding in lymphomas, even more rare is the location in the skin of which only 16 cases have been reported in the literature. It is important to be aware of these findings in the differential diagnosis with other reactive or neoplastic entities that are more often accompanied by mixed inflammatory infiltrate, and with a different prognosis and treatment.© Dermatología Revista Mexicana
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Utilidad de la biopsia de médula Ósea (MO) en el diagnostic de las neoplasias mieloproliferativas (NMP)
(2016)
Tovar-Bobadilla, José Leonard
;
Ortíz Hidalgo, Carlos Federico
A diagnostic approach of myeloproliferative neoplasms, according to the 2008 WHO classification system for hematological malignancies, has to consider clinical, molecular, and cytogenetic information as well as bone marrow histology. A diagnosis of chronic myeloid leukemia requires the presence of BCR-ABL-1, and the Philadelphia chromosome-negative (Ph-1-negative) myeloproliferative neoplasms constitute three main subtypes, including primary myelofibrosis, polycythemia rubra vera, and essential thrombocythemia. These three Ph-1-negative myeloproliferative neoplasms share many pathogenic characteristic such as JAK2 mutations; however, they differ in prognosis, progression to myelofibrosis, and risk of leukemic transformation. There are currently various major points of interest in bone marrow examination in myeloproliferative neoplasms. One is the morphology of megakaryocytes, which are the hallmark of Ph-1-negative myeloproliferative neoplasms and play a crucial role in separating the different subtypes of myeloproliferative neoplasms. Another is reticulin fibrosis or collagen fibrosis, which may only be detected on a bone marrow biopsy specimen by reticulin and trichrome stains, respectively, and immunohistochemistry and certain molecular techniques may be applied in bone marrow biopsies as supporting evidence of certain features of myeloproliferative neoplasms. (Gac Med Mex. 2016;152:407-18)© Gaceta Médica de México
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Sarcoma sinovial pobremente diferenciado de pared del tórax con características rabdoides
(2023)
Canchola-Ibarra, Aranza Odeth
;
Ortíz Hidalgo, Carlos Federico
We report a rare case of a poorly differentiated synovial sarcoma (SS) with rhabdoid features. A 33-year-old woman was referred to our hospital with a chest wall tumor. MRI revealed a diffuse mass that invaded the pleura and extended into the esophagus, aorta, diaphragm and pancreas. Histopathological examination of the neoplasm showed it to be composed of sheets of small/medium cells with rhabdoid morphology, consisting of round, eccentrically localized nuclei, conspicuous nucleoli, and eosinophilic cytoplasm. Immunohistochemical studies demonstrated the tumor cells to be positive for TLE1, Bcl-2, EMA, CAM5.2, CD138 and CD56 and negative for desmin, smooth muscle actin or S100 protein. Fluorescent in-situ hybridization technique, performed on the paraffin section, showed SS18 gene rearrangement in the nuclei of the tumor cells. Poorly differentiated SS with “rhabdoid” features was diagnosed. This is only the 8 th case of a SS with “rhabdoid” features reported to date.
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George H. Whipple. Premio Nobel en Fisiología y Medicina en 1934. La enfermedad de Whipple, la anemia perniciosa y otras contribuciones a la medicina
(2002-07)
Ortíz Hidalgo, Carlos Federico
George Hoyot Whipple (1878-1976) was awarded the Nobel Prize in Physiology and Medicine in 1934, along with Minot and Murphy for their studies in pernicious anemia. Whipple's name has been given to the bacterial disease which he describes in 1907 that we know today as Whipple's disease or intestinal lipodystrophy. He gave the name of thalasemia to the Mediterranean anemia of Cooley, and made diverse contributions to hematology and general pathology. He worked with William Welch in the Department of Pathology at Johns Hopkins Hospital and later became director of the University of Rochester. He died in 1976 at the age of 98.© Gaceta Medica de México
1 15Scopus© Citations 4
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Tumor híbrido de la vaina del nervio periférico, con componentes de schwannoma mixoide, schwannoma tipo neuroblastoma y perineuroma
(2021)
Macari-Jorge, Andrés
;
Ortíz Hidalgo, Carlos Federico
A 43-year-old female presented with an oval eccentric solid lesion fixed to the submandibular gland. The tumor was composed of bland spindle cells embedded in a myxoid stroma with focal areas showing large cellular rosettes. Both areas were positive for S100 protein and glial fibrillary acidic protein. Some of the elongated spindle cells were also positive for epithelial membrane antigen, and glucose transporter 1, indicating perineurial cell differentiation. A diagnosis of hybrid tumor with myxoid schwannoma, neuroblastoma-like schwannoma and perineuroma components was rendered. The lesion was resected completely and has not recurred after eight months of resection. ©Gaceta Mexicana de Oncología
1 19Scopus© Citations 1
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Tumor de Küttner (sialoadenitis crónica esclerosante). Estudio clinicopatológico e inmunohistoquímico de 8 casos de una entidad poco reconocida
(2007)
Martínez Consuegra, Nayeli
;
Baquera Heredia, Javier
;
Sánchez Cisneros, Rodolfo
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Márquez Rocha, María Luisa
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Ortíz Hidalgo, Carlos Federico
Objective: To present the clinical-pathological characteristics of Küttner's tumour (KT) or chronic sclerosing sialadenitis. Material and method: We studied 8 cases of KT that were graduated histologically according to the Seifert grading system. An immunohistochemistry panel including CD20, CD3, and keratin AE1-3 was performed. ©Acta Otorrinolaringológica Española
Scopus© Citations 3 1 7
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Cutaneous sclerosing perineurioma of the digits: an uncommon soft-tissue neoplasm. Report of two cases with immunohistochemical analysis
(2003)
Canales-Ibarra, Claudia
;
Magariños, Gabriel
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Olsoff-Pagovich, Paul
;
Ortíz Hidalgo, Carlos Federico
Background: Cutaneous sclerosing perineurioma is a recently characterized, uncommon tumor composed of perineurial cells, which exhibits immunoreactivity for epithelial membrane antigen (EMA). These lesions occur preferentially in children and young adults and usually develop as dermal or subcutaneous nodules in the hands or palms. Methods: We report two cases of cutaneous sclerosing perineurioma in young patients without stigmata of neurofibromatosis. Histologically, these lesions were well-circumscribed masses and were characterized by a variable number of epithelioid and spindle cells with wavy nuclei end elongated cytoplasmic processes embedded in a dense collagen stroma. © Journal of Cutaneous Pathology
2 6Scopus© Citations 39
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Primary Angiomatoid Melanoma as an Exceptional Morphologic Pattern in Cutaneous Melanoma. A Case Report and Review of the Literature
(Elsevier, 2015)
Ramos-Rodríguez, Guillermo
;
Ortíz Hidalgo, Carlos Federico
We report a case of angiomatoid melanoma on the right thigh of a 59-year-old man. The histologic growth pattern of the tumor mimicked vascular proliferation, and the cells lining the pseudovascular spaces were positive for protein S-100, HMB-45, and MITF-1. The differential diagnosis is with angiosarcoma and pseudovascular adenoid squamous cell carcinoma. The case we present is the fifth reported to date. © 2014 Elsevier España, S.L.U. and AEDV. All rights reserved.
Scopus© Citations 6 1 13
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Intra-abdominal Follicular Dendritic Cell Sarcoma With Marked Pleomorphic Features and Aberrant Expression of Neuroendocrine Markers: Report of a Case With Immunohistochemical Analysis
(2007)
Padilla Rodríguez, Álvaro Lezid
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Bembassat, Miguel
;
Lopez, Miguel
;
Ortíz Hidalgo, Carlos Federico
Follicular dendritic cell sarcoma (FDCS) is a very rare malignant tumor arising most frequently in lymph nodes with only few reports of extranodal locations. We report the case of a 35-year-old man with a large retroperitoneal mass. Histologically the tumor was composed of highly pleomorphic cells exhibiting some uncommon features such as an epithelioid appearance, cystic spaces, and multinucleated cells with morphologic features of emperipolesis. Immunohistochemically the neoplastic cells were immunoreactive for CD21, CD23 and CD35. A previously unreported expression of neuroendocrine markers (Synaptophisyn and Neuron-Specific-Enolase) was present. Ultrastructurally no neuroendocrine secretory granules were detected. FDCS can mimic a wide variety of other malignant tumors, and a correct diagnosis requires exclusion of other neoplasms and immunohistochemical confirmation. © 2007 Lippincott Williams & Wilkins, Inc.
1 8Scopus© Citations 16
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Tumor adenomatoide del aparato genital. Estudio clinicopatológico e inmunohistoquímico de 9 casos
(2006)
Canedo-Patzi, Ana Marcela
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De León-Bojorgea, Beatriz
;
Ortíz Hidalgo, Carlos Federico
Objetive: Describe the histological and immunohistochemical features of nine genital tract adenomatoid tumors . Material and methods: Nine cases of adenomatoid tumors were collected from the files of the Pathology department at a private hospital (ABC Hospital). Tumors were studied from a histological and inmunohistochemical perspective. Results: Eight women and one man were studied. Age range was 28–54 yrs. Tumors were located in the uterus (seven), fallopian tube (one) and epididymis (one). Tumor size ranged from 0.4 to 5.8 cm. We observed three histological patterns: adenoid, angiomatoid and solid. Arrangement of the neoplastic tubules around fascicles of smooth muscle; angiomatoid pattern with a peripheral location, and solid and adenoid patterns with a central location in the tumor were some of the observed histological features. Immunohistochemically all tumors exhibited strong and diffuse positivity for calretinin and AE1/AE3. Thrombomodulin was positive in all tumors (focal and weak in angiomatoid pattern and diffuse and strong in adenoid and solid patterns). The CK5/6 antibody was positive in seven tumors (diffuse in three and focal in four). Two tumors were negative for this marker. All tumors were negative for CD31.©Gaceta Médica de México
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Ortíz Hidalgo, Carlos Federico

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