Ortíz Hidalgo, Carlos Federico

Main Affiliation

Facultad de Ciencias de la Salud - CampCM

Preferred name

Official Name

Ortíz Hidalgo, Carlos Federico

ORCID

0000-0002-2456-7402

Researcher ID

DWN-7833-2022

Scopus Author ID

7003618204

Now showing 1 - 10 of 73

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Sarcoma histiocítico. Criterios diagnósticos histopatológicos e inmunohistoquímicos y sus diagnósticos diferenciales
(2011)
García-Gutiérrez, Mónica
;
Ortíz Hidalgo, Carlos Federico
Histiocytic sarcoma (HS) is a rare malignant tumor, originating from bone marrow-derived myeloid stem cells, showing morphologic and immunophenotipic evidence of mature tissue histiocytes (macrophages). HS arises in lymph nodes and extranodal sites such as skin, soft tissues and particularly the gastrointestinal tract, often presenting with clinically advanced disease and pursuing and aggressive clinical course. The diagnosis of HS relies predominantly on the immunohistochemical features of the histiocytic lineage, and the exclusion of large cell lymphoma and other poorly differentiated large cell malignancies such as, carcinomas and melanomas.© Gaceta Mexicana de Oncología
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Mujer de 33 años de edad con leve dolor toracoabdominal derecho de seis años de evolución, súbitamente agudizado
(2011)
Cárdenas-Escudero, Mara A.
;
Shuchleib-Chaba, Samuel
;
Muruchi-Garrón, Germán Walter
;
León-Bojorge, Beatriz de
;
Ortíz Hidalgo, Carlos Federico
We present a case of a benign hybrid nerve sheath tumor showing features of both cellular schwannoma and perineurioma. The patient was a 33 year-old female who presented with a 6 month history of pain in the thorax-lumbar region. Axial CT and MIR images showed and homogeneously enhancing solid oval mass involving the left paravertebra region in contact with the vertebral foramina T9-T11. Morphologically the tumor presented a well formed capsule and showed a uniform highly spindle cell proliferation. The spindle cells were arranged in whorls and intersecting fascicles with focal intervening sclerosis and relatively uniform cellularity with a prominent perivascular lymphocytic infiltrate. No cytological atypia, necrosis or mitoses were present. A second cell component was present composed of spindle-shaped cells with inconspicuous bipolar, pale, eosinophilic cytoplasm with oval nuclei. By immunohistochemistry there was a diffuse staining for S-100, and the elongated bipolar cells were EMA, Glut-1 and Claudin-1. To our knowledge this is the first reported case of a hybrid cellular schwannoma/perineurioma. ©Gaceta Médica de México
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Linfoma anaplásico de células grandes : estudio clínico-patológico e inmunohistoquímica de 20 casos clasificados de acuerdo a la revisión de la Organización Mundial de la Salud de neoplasias linfoides de 2016
(2022)
Sevilla Lizcano, Diana Brisa
;
Ortíz Hidalgo, Carlos Federico
Anaplastic large cell lymphoma (ALCL) is a type of non-Hodgkin lymphoma composed of CD30-positive neoplastic cells. The 2016 revision of the WHO classification of lymphoid neoplasms includes anaplastic lymphoma kinase (ALK) positive, ALK negative and breast implant associated ALCL. ALCL have distinct clinical and prognostic features between positive and negative cases. ALK-1 positive cases mostly occur in the first three decades of life while patients with ALK-1 negative are older. ALCL exhibit a very broad range of cytology appearances that include common pattern, lymphohistiocytic pattern, small-cell pattern, Hodgkin-like pattern and composite pattern. By definition, ALCL show strong CD30 staining on the cell membrane and in the Golgi region and the majority are epithelial membrane antigen positive, express one or more T-cell or Natural Killer antigens and are constantly negative for Epstein-Barr virus. We present the clinicopathologic and immunohistochemical analysis of 20 cases of ALCL studied at a single institution, classified according to the 2016 revision of lymphoid neoplasms. Nine cases were ALK-1 positive, ten ALK-1 negative, and one case as a breast implant associated ALCL ALK-1 negative. © 2017 Sociedad Mexicana de Oncología.
2 10Scopus© Citations 1
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History of Leukemia, Revisited
(Springer Science and Business Media LLC, 2025)
Ortíz Hidalgo, Carlos Federico
Purpose of the Review: Provide a general historical overview of leukemia, emphasizing the early discoveries that led to its characterization. Recent Findings: Leukemia recognition began in the late 19th century with the advent of the microscope. Leeuwenhoek and Swammerdam described erythrocytes, while Lieutaud first observed globuli albicantes, later identified as lymphocytes by Hewson. Early case studies by Velpeau, Donné, Bennett, Craigie, Virchow, and Fuller suggested that leukocytosis could occur without infection. Virchow coined the term “leukemia,” while Bennett proposed “leucocythemia.” Neumann identified the bone marrow as the source of blood cells and leukemia, coining the term “myelogenous leukemia,” and Ehrlich classified leukemia into myeloid and lymphoid types. In 1914, Boveri linked chromosomal abnormalities to cancer, and in 1960, Nowell and Hungerford discovered the Philadelphia chromosome. The use of mustard gas in WWI led to the development of chemotherapy drugs like chlorambucil and busulfan. The Human Genome Project further advanced leukemia diagnosis and treatment. Summary: Leukemia, like many diseases, has evolved due to changes in causative factors such as viruses, bacteria, and genetic mutations, which have impacted its pathogenesis and treatment. It will undoubtedly continue to evolve, with new scientists working towards a cure for this devastating disease. ©The author ©Current Oncology Reports ©Springer Science and Business Media LLC.
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Expresión de CD-34 en el elastofibroma. Estudio clinicopatológico, histoquímico e inmunohistoquímico de cuatro casos
(1999-01)
Ruelas-Villavicencio, Ana Lilia
;
Aponte Paredes, Paola Susana
;
Ortíz Hidalgo, Carlos Federico
Objetivo. Explorar la expresión imunohistoquímica de células en casos de elastofibroma y evaluar cuatro técnicas histoquímicas para fibras elásticas. Material y métodos. Se obtuvieron cuatro elastofibromas de los archivos del departamento de patología del Hospital ABC. Todos los pacientes fueron mujeres cuyas lesiones se encontraron en la región subescapular. Se realizó inmunohistoquímica para CD34, actina, desmina, vimentina, proteína S-100 y bcl-2 y se evaluaron cuatro métodos para fibras elásticas (Verhoff, Gallego, Reyes-Mota y Russel-Movat). Resultados. En los cuatro casos habían numerosos miofibroblastos (positivos a la vimentina/actina/desmina). Además encontramos células dendríticas distribuidas irregularmente, positivas al CD34. Las tinciones de Verhoff y Reyes-Mota son las que mejor resaltan el componente elástico. El método de Russel-Movat es útil para distinguir diferentes componentes de tejido conectivo. Conclusión. Las células del elastofibroma originalmente se consideraron fibroblastos. La presencia de vimentina/actina/desmina sugiere que existe una población de miofibroblastos. Describimos por primera vez, células fusiformes y dendríticas, positivas al CD34 (QBend/10) distribuidas irregularmente en toda la lesión. Estas células pueden ser población reactiva de células del ®sistema dendrítico dérmico¼. No encontramos inmunorreactividad para bcl-2 en las células fusiformes y dendríticas © Revista de Investigación Clínica
2Scopus© Citations 6 11
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Enfermedad de Castleman. Análisis histopatológico e inmunohistoquímico de treinta y nueve casos
(2017)
Brisa Sevilla-Lizcano, Diana
;
Frias-Soria, Christian Lizette
;
Ortíz Hidalgo, Carlos Federico
Introduction: Castleman disease (CD) is a rare lymphoproliferative that comprises two distinct clinical subtypes (unicentric and multicentric) and has two basic histopathology patterns that are hyaline-vascular (HV) and plasma-cell (PC) type. Some cases of multicentric PC disease are associated with HHV-8 infection. Objective: To present the histopathologic and immunohistochemical characteristics of 39 cases of CD. Methods: A review of cases with the diagnosis CD from the files of the Department of Pathology of the ABC Medical Centre in Mexico City was performed. Thirty-nine cases of CD were identified, and a detailed paraffin immunophenotypic study of 9 of them was completed using desmin, cytokeratin OSCAR (CO) and Epidermal growth factor receptor (EGFR), to evaluate the dendritic cell population. ©Gaceta Médica de México.
2 10Scopus© Citations 9
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Well-differentiated (Marschalko-type) plasmacytoma resembling thyroid follicular structures
(2008)
Lara-Torres, César Octavio
;
Ortíz Hidalgo, Carlos Federico
Dear Editor: Plasma cell neoplasms may display diverse cytoarchitectural variations, including a diffuse, nested, paragangliomatous, and angiomatoid arrangements [1]. We present herein a case of a well-differentiated (Marschalko-type) plasmacytoma in which neoplastic plasma cells arranged in a pseudofollicular configuration resemble thyroid follicles filled with ‘colloid-like’ material. © Journal of Hematopathology
1 3Scopus© Citations 3
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Diffuse Membranous Immunoreactivity of CD56 and Paranuclear Dot-like Staining Pattern of Cytokeratins AE1/3, CAM5.2, and OSCAR in Undifferentiated (Embryonal) Sarcoma of the Liver
(2010)
Pérez-Gómez, Rosa María
;
Soria-Céspedes, Danny
;
León-Bojorge, Beatriz de
;
Ortíz Hidalgo, Carlos Federico
To the editor: Undifferenced (embryonal) sarcoma of the liver (UESL) is an uncommon, rapidly growing malignant spindle cell tumor that usually occurs in children and young adults, as characterized by Stocker and Ishak in 1978. © Applied Immunohistochemistry & Molecular Morphology
2 18Scopus© Citations 11
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Carcinoma epidermoide orofaríngeo metastásico en ganglios linfáticos cervicales asociado a los subtipos 16 y 45 del virus del papiloma humano (VPH). estudio clínico, morfológico y molecular de dos casos
(2013)
Soria-Céspedes, Danny
;
Canchola Aguilar, Guadalupe
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Lara-Torres, César Octavio
;
Sánchez-Marle, Juan Felipe
;
Hernández-Peña, Roberto Enrique
Human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma has been identified as a distinct entity within squamous cell carcinoma of the head and neck. In contrast to carcinomas associated with alcohol and/or tobacco, this subtype occurs at younger age, with frequent absence of classic risk factors, correlation with oral sexual habits, strong predilection for the palatial tonsils and the base of the tongue (lingual tonsils), basaloid or lymphoepithelial differentiation, higher degree of radiosensitivity, and overall better survival. We report two cases of lymph node, metastatic, poorly differentiated squamous cell carcinoma that were positive by immunohistochemistry for p16 with detection of HPV-16 and HPV-45 by PCR. (Gac Med Mex. 2013;149:673-9) © Gaceta Médica de México
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Disgerminoma «anaplásico» de ovario en una mujer de 23 años de edad. Estudio inmunohistoquímico de un caso, con énfasis en el diagnóstico diferencial
(2008)
Piña-Oviedo, Sergio
;
Sereno, B.
;
Ortíz Hidalgo, Carlos Federico
El disgerminoma pertenece al grupo de tumores germinales de ovario y representa la contrapartida del seminoma testicular. Es un tumor poco frecuente que se presenta en pacientes jóvenes y cuyo pronóstico es favorable. Histológicamente, las células neoplásicas semejan células germinales primordiales; células grandes con abundante citoplasma claro y/o eosinófilo, con núcleo grande y nucléolos eosinófilos prominentes. Estas células se distribuyen a manera de trabéculas o cordones y están rodeadas por estroma de tejido conectivo y linfocitos pequeños. Debido a estas características, es importante realizar un adecuado diagnóstico diferencial con otros tumores morfológicamente similares, así como emplear la inmunohistoquímica para su tipificación. Se presenta el caso de una paciente de 23 años con un tumor de ovario derecho que se diagnosticó como disgerminoma «anaplásico ». Este término se ha empleado en aquellos casos en que el tumor presenta alta celularidad, escaso estroma, pleomorfismo nuclear, un alto índice mitótico y datos de invasión vascular. Sin embargo, aún no se ha establecido un consenso con respecto a si el patrón histológico es útil o no para definir el comportamiento de esta variante del tumor.
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Ortíz Hidalgo, Carlos Federico

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