CRIS

Permanent URI for this communityhttps://scripta.up.edu.mx/handle/20.500.12552/1

Browse

Search Results

Now showing 1 - 9 of 9

Some of the metrics are blocked by your
consent settings
Biological Implications of the Intrinsic Deformability of Human Acetylcholinesterase Induced by Diverse Compounds: A Computational Study
(MDPI, 2024)
Alvarado, Ysaías J.
;
González-Paz, Lenin
;
Paz , José L.
;
Loroño-González, Marcos A.
;
Santiago Contreras, Julio
The enzyme acetylcholinesterase (AChE) plays a crucial role in the termination of nerve impulses by hydrolyzing the neurotransmitter acetylcholine (ACh). The inhibition of AChE has emerged as a promising therapeutic approach for the management of neurological disorders such as Lewy body dementia and Alzheimer’s disease. The potential of various compounds as AChE inhibitors was investigated. In this study, we evaluated the impact of natural compounds of interest on the intrinsic deformability of human AChE using computational biophysical analysis. Our approach incorporates classical dynamics, elastic networks (ENM and NMA), statistical potentials (CUPSAT and SWOTein), energy frustration (Frustratometer), and volumetric cavity analyses (MOLE and PockDrug). The results revealed that cyanidin induced significant changes in the flexibility and rigidity of AChE, especially in the distribution and volume of internal cavities, compared to model inhibitors such as TZ2PA6, and through a distinct biophysical-molecular mechanism from the other inhibitors considered. These findings suggest that cyanidin could offer potential mechanistic pathways for future research and applications in the development of new treatments for neurodegenerative diseases. ©The authors ©MDPI
25
Some of the metrics are blocked by your
consent settings
La responsabilidad de la voluntad ante las emociones, según la antropología agustiniana
(2017)
Tellez-Maqueo, David-Ezequiel
In this article, I would like to examine various representative passages by Augustine of Hippo about the relationship between will and emotions, to define the limits of responsibility of human action under the influence of the most intense passion, according to the author. Simultaneously, I will endeavor to determine the impact of stoic philosophy on in Augustine’s approach to the subject. ©Centro de Investigación Social Avanzada, A.C., 2022.
25 1
Some of the metrics are blocked by your
consent settings
La relación de la voluntad con las pasiones según Buenaventura de Bagnoregio y Tomás de Aquino
(2017)
Tellez-Maqueo, David-Ezequiel
Both Aquinas and Bonaventure have dedicated some passages of their commentary on Peter Lombard's Sentences to address the role of passions vis-à-vis the self-mastery performed by the will. In order to underscore the differences between both proposals, some authors (v.gr. N. LOMARDO, The Logic of Desire) have posed the existence of a better capability of will in Aquinas to rule the passions of the concupiscible and irascible appetites, as opposed to a less availability of the passions to be manageable in Bonaventure, seemingly due to a supposed autonomy of the passions before the will and as if they were an inherent 'threat' to virtue according to the latter. This article discuss to what extent that comparison portraits Bonaventure's opinion on the matter. © 2017 Vita e Pensiero/Pubblicazioni dell'Universitá Cattolica del Sacro Cuore.
16 2
Some of the metrics are blocked by your
consent settings
Una explicación neoplatónica del origen del mal moral en el comentario de Tomás de Aquino al De divinis nominibus
(2018)
Tellez-Maqueo, David-Ezequiel
Aunque la aproximación más común de Tomás de Aquino a la noción del mal moral se encuentra en su De malo, ese mismo tema lo trata en su Comentario al De divinis nominibus de Pseudo-Dionisio, donde el autor revela algunos elementos neoplatónicos en su postura sobre la presencia del mal moral en el mundo, partiendo de esta obra poco conocida. Para ilustrar dichos elementos, expongo en este artículo algunos conceptos ético-antropológicos importantes de Tomás de Aquino tomados de la fuente mencionada, buscando identificar el paralelismo existente entre Pseudo-Dionisio y Aristóteles con relación a pasiones como la concupiscencia y la iracundia. © Espíritu
18 1
Some of the metrics are blocked by your
consent settings
La ira en Tomás de Aquino y Casiano : dos aproximaciones en torno a un tema común
(Universidad Autónoma Metropolitana, Departamento de Filosofía, 2018)
Tellez-Maqueo, David-Ezequiel
Although Cassian's vision emphasizes the inconveniences wrought by anger in the moral life, Thomas Aquinas recognizes the validity of being angry at the right person and at the right time. This is an undeniable disagreement between both of them, as Michael Rota has noted. However, it is a fact that Cassian's positive view on the issue has not been highlighted enough. The aim of this article is to show the valuable psychological aspect that might be present in his doctrine on anger, and if there is any possible point of contact with Aquinas's account. © 2018 Universidad Autónoma Metropolitana, Department of Philosophy. All rights reserved.
28 2
Some of the metrics are blocked by your
consent settings
¿Es el esfuerzo una característica esencial de la voluntad? Una aproximación a William James desde la psicología de Tomás de Aquino
(2018)
Tellez-Maqueo, David-Ezequiel
William James puts forth the feeling of effort as an essential feature of the mil ¿n such a way that its presence would be an undeniable sign of a voluntary act, and its absence proves that the mil is missing. This historically accepted consideration has contributed to the prevailing assumption that the power of will depends on the more or less effort to execute an act: the more effort one puts into operation, the more will one have. The purpose of this article is to show a consideration of the will according to these terms disagree with Thomas Aquinas's vision, who teaches that there are voluntary actions that don't take hard work. As a result of the aquinian stance, the common belief that the most valuable actions are the most difficult ends up being disputable. © Veritas
Scopus© Citations 1 8 2
Some of the metrics are blocked by your
consent settings
<i>Repetition</i> and the Art of Writing Novels
(2022)
Tellez-Maqueo, David-Ezequiel
;
Rojas, Fernanda
<jats:title>Abstract</jats:title> <jats:p>In this paper we wish to analyze how Kierkegaard understood the art of writing novels, that is, as a way to express and develop the life-view of the author. We would like to argue that this notion, presented for the first time in <jats:italic>From the Papers of One Still Living</jats:italic> (1838), was put into practice in the short novel <jats:italic>Repetition</jats:italic> (1843), in which Kierkegaard used the biblical story of Job to explain the development of selfhood through the existential category of repetition. According to Kierkegaard, true repetition—which is the central category of the life-view he is trying to convey—helps the individual “recollect” the past correctly so he or she can reconcile with the present and grow into the future.</jats:p>
38 2
Some of the metrics are blocked by your
consent settings
Presencia de Agustín de Hipona y algunos filósofos antiguos en la noción filosófica de ira de Francisco de Sales
(2023)
Tellez-Maqueo, David-Ezequiel
This article aims to analyze Francis de Sales’s notion of anger from a philosophical perspective, something uncommon among their interpreters, more inclined to draw near him as a theologian. For this purpose, I’m putting the issue in context from the current debate in Ancient Philosophy between Seneca and Aristotle concerning the morality of anger and its anthropological value, followed by Augustine of Hippo’s account of anger. Secondly, I address some anthropological considerations on anger carried out by Francis de Sales through some Greek, Medieval and Monastic authors with whom his thought is related. Finally, I make an appraisal of the Salesian stance about the moral value of anger, emphasizing that Francis de Sales was not a Stoic thinker. At the same time, he separates himself from the Aristotelian position on the matter.©Revista Pensamiento, Universidad Pontificia Comillas, Departamento de Filosofía, Humanidades y Comunicación | Facultad de Ciencias Humanas y Sociales, Universidad de Comillas
43 2
Some of the metrics are blocked by your
consent settings
¿Cabe un voluntarismo en la explicación psicológica de Tomás de Aquino sobre las causas del mal moral?
(2020)
Tellez-Maqueo, David-Ezequiel
Most of the studies and commentaries on Thomas Aquinas such as those made from the scholastic and neo-scholastic perspective have emphasized the intelectualism of his thought. This intelectualism is based mainly but non exclusively on the ontological primacy of the intellect over the will, on the affirmation that the ignorance is one of the pivotal causes of evil actions, and on the fact that the will tends to follow the judgment of reason. Over the last fifty years, however, this reading has been the object of a critical revision by bringing to light in the texts the value of the will in Ethics and Philosophical Anthropology of Thomas Aquinas. Without the least intention of questioning the presence of intelectualist elements in his works, the aim of this paper is to reflect on some kind of psychological voluntarism in Thomas Aquinas, grounded on the role of the will in realizing the moral evil. © 2020 Pontificio Seminario Mayor San Rafael. All rights reserved.
13 1

CRIS

Browse

Filters

Settings

Sort By

Results per page

Search Results