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Author: search.filters.author.Villa, Antonio R.

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    Extended major histocompatibility complex haplotypes, ancestry and acute kidney transplant rejection in Mexicans
    (2011-07)
    Riquelme Mc Loughlin, M. Constanza
    ;
    Granados, Julio
    ;
    Acuña-Alonzo, Víctor
    ;
    Telich, Eduardo
    ;
    Mancilla-Urrea, Eduardo
    Introduction. Extended major histocompatibility complex (MHC) haplotypes are associated with several autoimmune diseases, and these appear to depend on ancestry. Objective. To evaluate the association of extended MHC gene frequencies, ancestry, and acute rejection. Material and methods. 127 living kidney transplant recipients who underwent kidney transplantation in Mexico City between January 2004 and October 2007 with follow up until October 2008. The primary outcome was biopsy proven acute rejection. Ancestry was considered as either Amerindian or admixtures with Caucasian, African or Oriental genes. Allele and haplotype frequencies were estimated for HLA A, B and DR loci. Hardy Weinberg (HW) and delta values were analyzed to test for linkage disequilibrium (LD).© Revista de Investigación Clínica
    Scopus© Citations 2  36  2
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    Prevalence of chronic kidney disease in the Kidney Early Evaluation Program (KEEP) México and comparison with KEEP US
    (2010)
    Obrador, Gregorio  
    ;
    García-García, Guillermo
    ;
    Villa, Antonio R.
    ;
    Rubilar, Ximena
    ;
    Olvera, Nadia
    The National Kidney Foundation Kidney Early Evaluation Program (KEEP) is a free community screening program aimed at early detection of kidney disease among high-risk individuals. A pilot phase of KEEP México began in 2008 in México City and Jalisco State. Adults with diabetes, hypertension, or family history of diabetes, hypertension, or chronic kidney disease (CKD) were invited to participate through advertising campaigns. All participants completed a questionnaire. Blood pressure, weight, and height were measured; blood and urine tests included albuminuria and serum creatinine to estimate glomerular filtration rate using the Modification of Diet in Renal Disease Study equation. Mean age of KEEP México City and KEEP Jalisco participants was 46 and 53 years, respectively; >70% were women. CKD prevalence was 22% in KEEP México City and 33% in KEEP Jalisco, not significantly different from reported KEEP US prevalence of 26%. CKD stages 1 and 2 were more frequent in KEEP México and stage 3 in KEEP US. In KEEP México City, CKD prevalence was higher than the overall prevalence among participants with diabetes (38%) or diabetes and hypertension (42%). Most KEEP México participants were unaware of the CKD diagnosis, despite that 71% in KEEP México City had seen a doctor in the previous year. CKD is highly prevalent, underdiagnosed, and underrecognized among high-risk individuals in México. KEEP is an effective screening program that can successfully be adapted for use in México.
    Scopus© Citations 107  24  2
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    Conocimiento y actitudes de oftalmólogos mexicanos acerca del consejo genético para retinoblastoma : análisis bioético
    (Permanyer, 2016)
    Morelos Herrera, Paula
    ;
    Casas-Martínez, María-de-la-Luz  
    ;
    Juárez Echenique, Juan Carlos
    ;
    Villa, Antonio R.
    Resumen: El retinoblastoma es el tumor intraocular más frecuente en la infancia. Se considera un cáncer hereditario, ya que hasta el 50% de los pacientes afectados tiene una mutación RB1 heredable, por lo que el asesoramiento genético es clave en la educación del paciente y sus familiares sobre los riesgos para desarrollar esta enfermedad, la posibilidad de heredarla en un futuro, y opciones reproductivas. No existen guías clínicas mexicanas sobre asesoramiento genético, y no hay datos bibliográficos sobre las posturas y conocimiento de los oftalmólogos mexicanos sobre este tema. Objetivo: Valorar el conocimiento médico y posturas éticas relacionadas con el asesoramiento genético para retinoblastoma, como la neutralidad durante el asesoramiento y el respeto a la autonomía del paciente y los familiares en la toma de decisiones. Material y métodos: Estudio observacional, prospectivo, transversal y analítico. Se utilizó un cuestionario electrónico de opción múltiple autoadministrado, que se envió por correo electrónico a oftalmólogos a nivel nacional. Resultados: Contestaron la encuesta 181 oftalmólogos. El 74% de los encuestados se ha visto en la necesidad de brindar este tipo de asesoramiento en alguna ocasión; sin embargo, una gran parte (73.5%) no tiene conocimiento sobre los patrones de herencia del retinoblastoma, ni de los aspectos bioéticos relativos al asesoramiento genético. ©Los autores © 2016 Sociedad Mexicana de Oftalmología.
    Scopus© Citations 1  8  2