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    Águeda de Catania: Santa patrona de las enfermedades de la glándula mamaria
    (2011-09)
    Ortíz Hidalgo, Carlos Federico  
    For those suffering from breast cancer, Agatha is their patron saint. She was a beautiful Christian maiden, from Catania, Sicily, who dedicated her life to God. As she rejected the love proposals of consul Quintiliano, she suffered cruel tortures. One of the tortures she suffered was to have her breast cut off, with iron shears, a detail that furnished to the Christian medieval iconography, the peculiar characteristic of Agatha. Catania honors Agatha as her patron saint and throughout the region around Mt. Etna. Saint Agatha’s feast day is February 5. All of those dedicated to the treatment and prevention of breast cancer are known as “the soldiers of Saint Agatha”.© Gaceta Médica de México.
    Scopus© Citations 2  39  1
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    In Vitro Evidence of Differential Immunoregulatory Response between MDA-MB-231 and BT-474 Breast Cancer Cells Induced by Bone Marrow-Derived Mesenchymal Stromal Cells Conditioned Medium
    (2022)
    Arenas Luna, Victor Manuel  
    ;
    Montesinos, Juan José
    ;
    Cortés-Morales, Víctor A.
    ;
    Cisneros, Bulmaro
    ;
    Navarro Betancourt, Refugio
    Inside tumors, cancer cells display several mechanisms to create an immunosuppressive environment. On the other hand, by migration processes, mesenchymal stromal cells (MSCs) can be recruited by different cancer tumor types from tissues as distant as bone marrow and contribute to tumor pathogenesis. However, the impact of the immunoregulatory role of MSCs associated with the aggressiveness of breast cancer cells by soluble molecules has not been fully elucidated. Therefore, this in vitro work aimed to study the effect of the conditioned medium of human bone marrow-derived-MSCs (hBM-MSC-cm) on the immunoregulatory capability of MDA-MB-231 and BT-474 breast cancer cells. The hBM-MSC-cm on MDA-MB-231 cells induced the overexpression of TGF-β, IDO, and IL-10 genes. Additionally, immunoregulation assays of mononuclear cells (MNCs) in co-culture with MDA-MB-231 and hBM-MSC-cm decreased lymphocyte proliferation, and increased proteins IL-10, TGF-β, and IDO while also reducing TNF levels, shooting the proportion of regulatory T cells. Conversely, the hBM-MSC-cm did not affect the immunomodulatory capacity of BT-474 cells. Thus, a differential immunoregulatory effect was observed between both representative breast cancer cell lines from different origins. Thus, understanding the immune response in a broader tumor context could help to design therapeutic strategies based on the aggressive behavior of tumor cells.
    Scopus© Citations 2  20  1