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Language: search.filters.language.EnglishSubject: search.filters.subject.Apparent diffusion coefficient

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    Delayed injection of polypyrrole doped with iodine particle suspension after spinal cord injury in rats improves functional recovery and decreased tissue damage evaluated by 3.0 Tesla in vivo magnetic resonance imaging
    (2017)
    Mondragón-Lozano, Rodrigo
    ;
    Ríos, Camilo
    ;
    Cruz, Guillermo J.
    ;
    Olayo, Maria G.
    ;
    Olayo, Roberto
    Background context: Traumatic spinal cord injury (SCI) causes irreversible damage with loss of motor, sensory, and autonomic functions. Currently, there is not an effective treatment to restore the lost neurologic functions. Purpose: Injection of polypyrrole-iodine(PPy-I) particle suspension is proposed as a therapeutic strategy. Study design: This is an in vivo animal study. Methods: This study evaluates the use of such particles in rats after SCI by examining spared nervous tissue and the Basso, Beattie, and Bresnahan (BBB) scale to evaluate the functional outcome. Diffusive magnetic resonance imaging (MRI) was employed to measure the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) as non-invasive biomarkers of damage after SCI. Copyright © 2016 Elsevier Inc. All rights reserved.
    Scopus© Citations 12  28  2