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    Item type:Publication,
    Relationship between inflammatory markers in human olfactory neural progenitor cells and antidepressant response
    (Elsevier, 2024)
    Flores-Ramos, Mónica
    ;
    Ramírez-Rodríguez, Gerardo Bernabé
    ;
    Guiza Zayas, Rodrigo
    ;
    Solares-Bravo, Melissa
    ;
    Rodríguez-Bores, Lorena
    Response to antidepressants is related to hippocampal neurogenesis integrity, a process mediated by neurotrophins, such as Brain Derived Neurotrophic Factor (BDNF). In turn, pro-inflammatory state appears to reduce neurogenesis, and has been associated with refractory depressive states. We propose to analyze the human neural progenitor cells derived from the olfactory epithelium (HNPCs-OE) as an indicator of neurogenesis in humans. Therefore, we compared the number and content of HNPCs-OE in depressed patients taking antidepressants, according to response to treatment. Twenty depressed patients were followed during eight weeks after antidepressant treatment was prescribed. At the end evaluation they were divided in two groups according to Hamilton depression rating scale (HDRS) scores: responders and non-responders. We compared the number and components of HNPCs-OE between groups and observed an elevation of interleukine-8 in those patients who do not achieve response to treatment, BDNF levels were no related to antidepressant response. ©Elsevier
    Scopus© Citations 2  11  1
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    Item type:Publication,
    Uso de antidepresivos y bioética
    (Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suarez, 2005)
    Casas-Martínez, María-de-la-Luz  
    La presente reflexión se ha realizado considerando a la bioética como una disciplina promotora del diálogo entre las ciencias bajo el marco de valores morales de la tradición occidental. Se aborda el tema del uso ético de antidepresivos en situaciones existenciales, más que en su uso terapéutico. Los objetivos son la revisión de los siguientes aspectos: a. Una visión antropológica. El hombre como ser carente, b. Los fines de la medicina y el uso de psicofármacos en situaciones limítrofes a la psicopatología. c. La medicalización de la vida humana. Se realiza un análisis de estos aspectos y una propuesta para el manejo de la tristeza en forma no medicamentosa, aceptando los límites humanos al acceso a la felicidad. © La autora © Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suarez © Archivos de Neurociencias.
      11  1