Nuclear Transcription Factor Kappa B Downregulation Reduces Chemoresistance in Bone Marrow-derived Cells Through P-glycoprotein Modulation

Loaiza, Brenda; Hernández Gutiérrez, Salomón; Montesinos, Juan José; Valverde, Mahara; Rojas, Emilio

doi:10.1016/j.arcmed.2016.05.004

Nuclear Transcription Factor Kappa B Downregulation Reduces Chemoresistance in Bone Marrow-derived Cells Through P-glycoprotein Modulation

Journal

Archives of Medical Research

ISSN

0188-4409

Date Issued

2016

Author(s)

Loaiza, Brenda

Hernández Gutiérrez, Salomón

Facultad de Ciencias de la Salud - CampCM

Montesinos, Juan José

Valverde, Mahara

Rojas, Emilio

Type

text::journal::journal article

DOI

10.1016/j.arcmed.2016.05.004

URL

https://scripta.up.edu.mx/handle/20.500.12552/2293

Abstract

Nuclear transcription factor kappa B (NF-κB) is associated with many types of refractory cancer. However, despite multiple strategies to treat cancer and novel target drugs, multidrug resistance still causes relapses. The best-characterized mechanism responsible for multidrug resistance involves the expression of the MDR-1 gene product, P-glycoprotein (P-gp). Because the direct inhibition of this protein is very toxic, other methods of multidrug resistance (MDR) regulation have been proposed. The MDR-1 promoter sequence contains a κB site, which is recognized by NF-κB. The aim of this work was to characterize whether NF-κB modulation changes the response of bone marrow-derived cells (BMDCs) to chemotherapy.