Hernández Gutiérrez, Salomón

Main Affiliation

Preferred name

Official Name

Hernández Gutiérrez, Salomón

ORCID

0000-0001-7923-0359

Researcher ID

DVV-7932-2022

Scopus Author ID

15739969000

Now showing 1 - 10 of 21

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Participation of Mesenchymal Stem Cells in the Tumor Process
(Springer Nature Singapore, 2024)
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Cisneros, Bulmaro
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Although most mesenchymal stem cell (MSCs) studies have focused on evaluating the safety and efficacy of their use as therapeutic agents in regenerative medicine, some recently published studies have highlighted the immunomodulatory role of MSCs in several pathologies, such as cancer. Multiple authors support the idea that MSCs play an essential role in tumor pathogenesis because MSCs can promote and facilitate tumor growth, angiogenesis, and metastasis. Additionally, MSCs may induce modulation of the immune response in favor of tumor growth by producing molecules such as cytokines, growth factors, and immunosuppressive molecules. Despite multiple underlying mechanisms by which MSCs promote tumor development and progression have been described, few reports have defined the mechanisms through which MSCs support immunosuppression. This chapter will present an overview analyzing the immunomodulatory properties of normal and tumor MSCs and their differences because the study of mechanisms that T-MSCs use to regulate the immune response could allow the design and development of novel strategies against cancer. ©The authors ©Springer.
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Ibervillea sonorae (S. Watson) Green a potential resource of bioactive compounds: Systematic analysis of a Mexican plant used in traditional medicine
(Elsevier, 2025)
Angulo Molina, Aracely
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Cristofaro, Valeria di
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Pieles, Uwe
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López Romero, Julio César
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Vidal Gutiérrez, Max
Ibervillea sonorae (S. Watson) Green (Cucurbitaceae) is a tuber succulent known as “wareke,” which grows in dry desert landscapes in northwestern Mexico and the southwestern United States. Indigenous tribes use I. sonorae as a remedy against cancer, inflammation, rheumatism, skin infections, and diabetes. The great popularity of wareke in traditional medicine has motivated various working groups to investigate its pharmacological properties. The antiproliferative, antitumoral, antifungal, hypoglycemic, antiinflammatory, antioxidant, and antimicrobial potential of this plant has been established. Chemical studies showed that I. sonorae is a potential resource of bioactive compounds, cucurbitacin-type triterpenoids, and phytosterols, the main secondary metabolites. The objective of this chapter is to systematically analyze the phytochemical knowledge of the plant (isolated and identified compounds), describe the biological activities of different extracts, isolated ingredients, and phytopreparations, and discuss their possible applications. ©The authors © 2025 Elsevier Inc.
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Células madre: buscando marcadores de superficie celular que predispongan compromiso de diferenciación cardiaca
(2018)
Lara Martínez, Luis Andrés
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Gutiérrez Villegas, Ingrid
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Actualmente las enfermedades cardiovasculares se han convertido en un serio problema para los sistemas de salud de todo el mundo, ya que son la principal causa de muerte y representan una enorme carga económica. Este problema ha sido abordado con diferentes estrategias, entre ellas con la ayuda de terapia celular, aunque sin resultados contundentes. Durante más de 20 años, se ha utilizado una gran variedad de células madre en diferentes modelos de infarto del miocardio. El uso de células madre cardiacas (CSC) parece ser la mejor opción, pero la inaccesibilidad y la escasez de estas células hacen que su uso sea muy limitado. Además, existe un riesgo elevado pues tienen que obtenerse directamente del corazón del paciente. A diferencia de las CSC, las células madre adultas derivadas de médula ósea o tejido adiposo, entre otras, representan una opción atractiva debido a su fácil accesibilidad y abundancia, pero sobre todo a la probable existencia de progenitores cardiacos entre sus diferentes subpoblaciones. En esta revisión hacemos un análisis de los marcadores de superficie presentes en CSC en comparación con otras células madre adultas, y sugerimos la preexistencia de células que comparten marcadores de superficie específicos con CSC, la presencia de un inmunofenotipo predecible, aunque en proporciones bajas, pero con un potencial de diferenciación cardiaca similar a las CSC, lo cual podría aumentar su valor terapéutico. Este estudio revela las nuevas perspectivas con respecto a la presencia de dichos marcadores, los cuales comprometerían algunas de estas subpoblaciones a diferenciarse a tejido cardiaco.
Scopus© Citations 2 36 1
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Pre-Conditioning with CDP-Choline Attenuates Oxidative Stress-Induced Cardiac Myocyte Death in a Hypoxia/Reperfusion Model
(2014)
González-Pacheco, Héctor
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Méndez-Domínguez, Aurelio
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López-Marure, Rebeca
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Vazquez-Mellado, Maria J.
Background: CDP-choline is a key intermediate in the biosynthesis of phosphatidylcholine, which is an essential component of cellular membranes, and a cell signalling mediator. CDP-choline has been used for the treatment of cerebral ischaemia, showing beneficial effects. However, its potential benefit for the treatment of myocardial ischaemia has not been explored yet. Aim: In the present work, we aimed to evaluate the potential use of CDP-choline as a cardioprotector in an in vitro model of ischaemia/reperfusion injury. Methods: Neonatal rat cardiac myocytes were isolated and subjected to hypoxia/reperfusion using the coverslip hypoxia model. To evaluate the effect of CDP-choline on oxidative stress-induced reperfusion injury, the cells were incubated with H₂O₂ during reperfusion. The effect of CDP-choline pre- and postconditioning was evaluated using the cell viability MTT assay, and the proportion of apoptotic and necrotic cells was analyzed using the Annexin V determination by flow cytometry.
Scopus© Citations 8 10 2
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El papel del factor de transcripción NF-κB en la célula cardíaca
(2005)
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Rojas del Castillo, Emilio
The signaling pathways that control the life-death switch of a cell are a prime interest in Modern Biology. To this respect, NF-κB has emerged as a decisive transcription factor in the cell’s response to apoptotic challenge and its effects on apoptosis have far-reaching consequences for normal development and/or homeostasis in many cells and tissues, including the immune system, hair follicles, and epidermal appendages, the liver, and nervous system. In this review we analyze the pivotal role of the transcription factor NF-κB in the normal functioning of the cardiac cell and its implication on some of the most frequent cardiac pathologies, such as ischemia-reperfusion injury, ischemic precondition, hypertrophy, atherosclerosis and cardiac arrest. While NF-κB is commonly found to be cytoprotective, there are a number of instances where it is proapoptotic depending on the inducing stimulus and the cell context. Significant progress has been made in understanding its mode of action and its interplay with other key factors. These studies identified many anti- and pro-apoptotic NFκB regulated genes that mediate its activity, these important new insights fuel hope that novel approaches will be developed to control the effects of NF-κB in cardiac pathologies.
4 2
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Increased CD47 and MHC Class I Inhibitory Signals Expression in Senescent CD1 Primary Mouse Lung Fibroblasts
(2021)
Hernández-Mercado, Elisa
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Prieto-Chávez, Jessica Lakshmi
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Arriaga-Pizano, Lourdes Andrea
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Mendlovic, Fela
Cellular senescence is more than a proliferative arrest in response to various stimuli. Senescent cells (SC) participate in several physiological processes, and their adequate removal is essential to maintain tissue and organism homeostasis. However, SC accumulation in aging and age-related diseases alters the tissue microenvironment leading to deterioration. The immune system clears the SC, but the specific scenarios and mechanisms related to recognizing and eliminating them are unknown. Hence, we aimed to evaluate the existence of three regulatory signals of phagocytic function, CD47, major histocompatibility complex class I (MHC-I), and calreticulin, present in the membrane of SC. Therefore, primary fibroblasts were isolated from CD1 female mice lungs, and stress-induced premature senescence (SIPS) was induced with hydrogen peroxide. Replicative senescence (RS) was used as a second senescent model. Our results revealed a considerable increment of CD47 and MHC-I in RS and SIPS fibroblasts. At the same time, no significant changes were found in calreticulin, suggesting that those signals might be associated with evading immune system recognition and thus averting senescent cells clearance.
Scopus© Citations 5 15 2
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Terapia celular y regeneración cardiaca. ¿Dónde estamos?
(2012)
Lara-Martínez, Luis Andrés
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Navarro Betancourt, Refugio
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La terapia celular es un recurso prometedor para el tratamiento de la cardiopatía isquémica; mediante un procedimiento como la infusión directa o intravascular de células troncales al tejido dañado, es posible restituir la capacidad funcional del corazón. A pesar del éxito de los ensayos en animales, en humanos no se han obtenido los resultados esperados; además, se presenta una serie de limitantes éticas y prácticas que ponen en duda los resultados. Se ha comprobado que la terapia con células troncales mejora las propiedades electromecánicas del tejido cardiaco como tal; sin embargo, el beneficio funcional aún es poco convincente, pero no desalentador. La realización de ensayos clínicos más grandes y el perfeccionamiento de técnicas de seguimiento no invasivas son necesarios para evaluar de manera integral el beneficio de la terapia celular. Por otra parte, el problema de la supervivencia de las células injertadas es un conflicto relevante, lo que hace que la eficiencia de las células a transferir sea variable y generalmente baja; esto es causado principalmente por tres procesos: apoptosis, isquemia e inflamación. Hasta ahora, el mecanismo más prometedor para incrementar la viabilidad del injerto es la sobreexpresión de proteínas antiapoptóticas. Sin duda, el principal desafío para la terapia celular será determinar la estirpe más adecuada para el tratamiento. En esta revisión se describen los principales tipos de células que a la fecha han sido propuestas para la regeneración cardiaca: las células troncales embrionarias, las células pluripotentes inducidas, las células derivadas de médula ósea, los mioblastos esqueléticos y las células de tejido adiposo, entre otras.
14 1
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In Vitro Evidence of Differential Immunoregulatory Response between MDA-MB-231 and BT-474 Breast Cancer Cells Induced by Bone Marrow-Derived Mesenchymal Stromal Cells Conditioned Medium
(2022)
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Montesinos, Juan José
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Cortés-Morales, Víctor A.
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Cisneros, Bulmaro
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Navarro Betancourt, Refugio
Inside tumors, cancer cells display several mechanisms to create an immunosuppressive environment. On the other hand, by migration processes, mesenchymal stromal cells (MSCs) can be recruited by different cancer tumor types from tissues as distant as bone marrow and contribute to tumor pathogenesis. However, the impact of the immunoregulatory role of MSCs associated with the aggressiveness of breast cancer cells by soluble molecules has not been fully elucidated. Therefore, this in vitro work aimed to study the effect of the conditioned medium of human bone marrow-derived-MSCs (hBM-MSC-cm) on the immunoregulatory capability of MDA-MB-231 and BT-474 breast cancer cells. The hBM-MSC-cm on MDA-MB-231 cells induced the overexpression of TGF-β, IDO, and IL-10 genes. Additionally, immunoregulation assays of mononuclear cells (MNCs) in co-culture with MDA-MB-231 and hBM-MSC-cm decreased lymphocyte proliferation, and increased proteins IL-10, TGF-β, and IDO while also reducing TNF levels, shooting the proportion of regulatory T cells. Conversely, the hBM-MSC-cm did not affect the immunomodulatory capacity of BT-474 cells. Thus, a differential immunoregulatory effect was observed between both representative breast cancer cell lines from different origins. Thus, understanding the immune response in a broader tumor context could help to design therapeutic strategies based on the aggressive behavior of tumor cells.
Scopus© Citations 2 20 1
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Adipose tissue-derived stem cells expressing cardiac progenitor markers: The best source of mesenchymal stem cells for cardiovascular repair?
(2014)
Navarro Betancourt, Refugio
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Baldassarri Ortego, Bruno
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Urquiza y Conde, F.
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At the present time a wide variety of stem cell lineages have been explored for the treatment of ischemic cardiomyopathy; currently, the reference cells for cardiac cell therapy are cardiac stem cells (CSCs), because these cells have a specific differentiation commitment into cardiac tissues [ 1 , 2 , 3 ]. In comparison with other cell types, this intrinsic commitment is inversely related to the capacity to differentiate into diverse tissues (Fig. 1). Despite this efficient differentiation, a specific immunophenotype for CSC identification is yet to be meticulously defined. In addition, the use of CSC in a clinical setting is severely hindered by their availability. These obstacles to the use of CSC for cardiac cell therapy have prompted the search for readily more attainable stem cell sources, even if they have a broader differentiation spectrum, such as mesenchymal stem cells (MSCs).
Scopus© Citations 5 11 1
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On the existence of cardiomesenchymal stem cells
(2015)
Navarro Betancourt, Refugio
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The most efficient cells for cardiac regeneration are myocardium-resident cardiac stem cells. However, the limited availability of these cells restricts their utility for cardiac cellular therapy. Mesenchymal stem cells can differentiate into a wide variety of tissues, but it is not simple to accurately direct cell differentiation into a specific lineage, such as cardiac tissue; this renders a low efficiency for cardiac regeneration therapy. Given the heterogeneity of mesenchymal stem cells, it may be possible to find specific stem cell subpopulations with a definite differentiation capacity toward cardiac lineage. A parameter to assess cardiac differentiation specificity could be surface marker expression; a population with an immunophenotype similar to cardiac stem cells may have a superior therapeutic value than unsorted mesenchymal stem cells. We hypothesize the existence of a cell line that combines the expression of cardiac stem cell surface markers with those of mesenchymal stem cells, a suitable name for this population is cardiomesenchymal stem cells (CMSC); such cells would be ideal for cardiac regeneration.
Scopus© Citations 5 10 2

Hernández Gutiérrez, Salomón

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