Data on sodium tetraborate as a modulation of hypertrophic intracellular signals

Roque-Jorge, J.; Hernández Gutiérrez, Salomón; Díaz-Rosas, Guadalupe; García-Chéquer, Adda Jeanette; Lopez-Torres, Adolfo; Contreras-Ramos, Alejandra

doi:10.1016/j.dib.2021.106889

Data on sodium tetraborate as a modulation of hypertrophic intracellular signals

Journal

Data in Brief

ISSN

2352-3409

Date Issued

2021

Author(s)

Roque-Jorge, J.

Díaz-Rosas, Guadalupe

García-Chéquer, Adda Jeanette

Lopez-Torres, Adolfo

Contreras-Ramos, Alejandra

Type

text::journal::journal article

DOI

10.1016/j.dib.2021.106889

URL

https://scripta.up.edu.mx/handle/20.500.12552/4358

Abstract

The present work benefits the use of sodium tetraborate to prevent and treat hypertrophic cardiac. The data obtained from the work could serve as a reference point to compare with data obtained in vivo studies with cardiac damage. This research will be an advantage for future researches to stimulate the ones focused on developing food supplements to prevent heart diseases such as cardiac hypertrophic. This article also indicates the data on the optimal concentration of isoproterenol as an inducer of hypertrophy in cardiomyocytes. Also, data of the cytotoxic effect of sodium tetraborate on normal cardiomyocytes is revealed. Finally, data of viability, cell size, proliferation nuclear antigen (PCNA) and apoptosis is shown. The expression of transcription factors linked to hypertrophy such as GATA-4, MEF2c, NFAT, CDk9, and myogenin was also quantified by immunofluorescence. The mRNA expression of adrenergic receptors (alpha and beta), AKT1 and Erk1 / 2 and genes of early response to hypertrophy (c-myc, c-fos, c-jun) are also shown as Cts of RT-qPCR. GAPDH and 18 s were used as housekeeping genes.