Tumor híbrido de la vaina del nervio periférico, con componentes de schwannoma mixoide, schwannoma tipo neuroblastoma y perineuroma

A 43-year-old female presented with an oval eccentric solid lesion fixed to the submandibular gland. The tumor was composed of bland spindle cells embedded in a myxoid stroma with focal areas showing large cellular rosettes. Both areas were positive for S100 protein and glial fibrillary acidic protein. Some of the elongated spindle cells were also positive for epithelial membrane antigen, and glucose transporter 1, indicating perineurial cell differentiation. A diagnosis of hybrid tumor with myxoid schwannoma, neuroblastoma-like schwannoma and perineuroma components was rendered. The lesion was resected completely and has not recurred after eight months of resection. ©Gaceta Mexicana de Oncología