Intra-abdominal Follicular Dendritic Cell Sarcoma With Marked Pleomorphic Features and Aberrant Expression of Neuroendocrine Markers: Report of a Case With Immunohistochemical Analysis

Padilla Rodríguez, Álvaro Lezid; Bembassat, Miguel; Lopez, Miguel; Ortíz Hidalgo, Carlos Federico

doi:10.1097/01.pai.0000213113.50849.9e

Intra-abdominal Follicular Dendritic Cell Sarcoma With Marked Pleomorphic Features and Aberrant Expression of Neuroendocrine Markers: Report of a Case With Immunohistochemical Analysis

Journal

Applied Immunohistochemistry & Molecular Morphology

ISSN

1541-2016

Date Issued

2007

Author(s)

Padilla Rodríguez, Álvaro Lezid

Bembassat, Miguel

Lopez, Miguel

Type

Resource Types::text::journal::journal article

DOI

10.1097/01.pai.0000213113.50849.9e

URL

https://scripta.up.edu.mx/handle/20.500.12552/2487

Abstract

Follicular dendritic cell sarcoma (FDCS) is a very rare malignant tumor arising most frequently in lymph nodes with only few reports of extranodal locations. We report the case of a 35-year-old man with a large retroperitoneal mass. Histologically the tumor was composed of highly pleomorphic cells exhibiting some uncommon features such as an epithelioid appearance, cystic spaces, and multinucleated cells with morphologic features of emperipolesis. Immunohistochemically the neoplastic cells were immunoreactive for CD21, CD23 and CD35. A previously unreported expression of neuroendocrine markers (Synaptophisyn and Neuron-Specific-Enolase) was present. Ultrastructurally no neuroendocrine secretory granules were detected. FDCS can mimic a wide variety of other malignant tumors, and a correct diagnosis requires exclusion of other neoplasms and immunohistochemical confirmation. © 2007 Lippincott Williams & Wilkins, Inc.