Reduced quality of life impacts knowledge and type of informed consent in rheumatoid arthritis patients
Journal
Clinical and Experimental Rheumatology
ISSN
1593-098X
Publisher
Clinical and Experimental Rheumatology S.A.S
Date Issued
2019
Author(s)
Pascual-Ramos, Virginia
Contreras-Yáñez, Irazú
Ruiz, Daniel
Type
text::journal::journal article
Abstract
Objectives: Informed consent (IC) is an ethical process required in human subject research. Primary objective was to determine factors associated to poor knowledge of IC content (PK) in patients from an early rheumatoid arthritis cohort. Methods: The cohort initiated in 2004, had assistant and research purposes (NCT03389711). At inclusion, each patient selected 1 of 4 options of the IC form; options ranged from broad consent (patient’s data could be used for research) to patient denied to have his/her data used. Once enrolled, patients had regular assessments. Up to May 2017, the cohort had 146 patients with (median, range) follow-up of 8.8 years, (4.3-11.9) and 143 agreed to participate in a cross-sectional study; patients had scheduled rheumatic evaluations; additionally, a social worker applied a questionnaire that addressed objective described. PK was established by the borderline performance method. Multiple regression models were applied to investigate factors associated to PK. Results: At cohort inclusion, patients were primarily middle-aged (38.3±13.1 years) females (88.9%), with high disease activity (DAS28: 5.8 [4.6-6.8)] and poor quality of life (SF-36: 42 [29-59]). All the patients gave broad IC. At study entry, 35-41.3% of them had PK; longer follow-up and lower SF-36 scores at cohort inclusion, were associated to PK. In addition, 79.7% of the patients had DAS28-remission and 67.1% had SF-36 scores within normal range; interestingly, only 49% of the patients considered broad re-consent and these patients had poorer SF-36 emotional subscore than their counterpart (79±23 vs. 87±1, p=0.02). Conclusions: Poor quality of life impacts the autonomy of RA patients. © The authors © Clinical and Experimental Rheumatology ©
License
Acceso abierto
How to cite
Pascual Ramos, V., Contreras Yáñez, I., Ruiz, D. y Casas Martínez, M. de la L. L. (2019). Reduced quality of life impacts knowledge and type of informed consent in rheumatoid arthritis patients. Clinical and experimental rheumatology, 37 (2), 186-192.