Carcinoma epidermoide orofaríngeo metastásico en ganglios linfáticos cervicales asociado a los subtipos 16 y 45 del virus del papiloma humano (VPH). estudio clínico, morfológico y molecular de dos casos
Journal
Gaceta Médica de México
ISSN
0016-3813
Date Issued
2013
Author(s)
Soria-Céspedes, Danny
Canchola Aguilar, Guadalupe
Lara-Torres, César Octavio
Sánchez-Marle, Juan Felipe
Hernández-Peña, Roberto Enrique
Type
text::journal::journal article
Abstract
Human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma has been identified as a distinct entity within squamous cell carcinoma of the head and neck. In contrast to carcinomas associated with alcohol and/or tobacco, this subtype occurs at younger age, with frequent absence of classic risk factors, correlation with oral sexual habits, strong predilection for the palatial tonsils and the base of the tongue (lingual tonsils), basaloid or lymphoepithelial differentiation, higher degree of radiosensitivity, and overall better survival. We report two cases of lymph node, metastatic, poorly differentiated squamous cell carcinoma that were positive by immunohistochemistry for p16 with detection of HPV-16 and HPV-45 by PCR. (Gac Med Mex. 2013;149:673-9) © Gaceta Médica de México