Validation of an equation for free calcium estimation: accuracy improves after adjustment for phosphate and CO2

Ramirez-Sandoval, Juan C.; Diener-Cabieses, Pablo; Gutiérrez-Valle, Fabián; Ley-Tapia, Sofía; Pastrana-Brandes, Santiago; Galindo, Pablo E.; Fagundo, Reynerio; Moreno-Yañez, Mauricio; Reza-Albarrán, Alfredo Adolfo; Correa-Rotter, Ricardo

doi:10.1007/s11255-022-03170-z

Validation of an equation for free calcium estimation: accuracy improves after adjustment for phosphate and CO2

Journal

International Urology and Nephrology

ISSN

1573-2584

Date Issued

2022

Author(s)

Ramirez-Sandoval, Juan C.

Diener-Cabieses, Pablo

Gutiérrez-Valle, Fabián

Ley-Tapia, Sofía

Pastrana-Brandes, Santiago

Galindo, Pablo E.

Fagundo, Reynerio

Moreno-Yañez, Mauricio

Reza-Albarrán, Alfredo Adolfo

Correa-Rotter, Ricardo

Type

Resource Types::text::journal::journal article

DOI

10.1007/s11255-022-03170-z

URL

https://scripta.up.edu.mx/handle/20.500.12552/2181

Abstract

Purpose: Free calcium is the gold standard for diagnosis of calcium disorders, although calcium assessment is routinely performed by albumin-adjusted calcium. Our objective was to develop a novel-specific correction equation for free calcium employing serum total calcium and other analytes. Methods: Retrospective single-center cohort study. A new equation for free calcium assessment was formulated from data of hospitalized patients (n = 3481, measurements = 7157) and tested in a validation cohort (n = 3218, measurements = 6911). All measurements were performed simultaneously from the same blood draw. © International Urology and Nephrology