Effect of the polymorphism BDNF rs6265 G/A in Mexican outpatient children with autism spectrum disorders
Journal
Salud Mental
ISSN
0185-3325
Date Issued
2018
Author(s)
Morales Marín, Mirna Edith
Aguilar, Miriam
Albores, Lilia
Ballesteros, Ana
Castro, Xóchitl
Chicalote, Carlos
Gómez, Amalia
Gutiérrez, Nora
Lanzagorta, Nuria
López, Fernando
Márquez, Carla
Morales, Nimsi
Náfate, Omar
Sánchez, Patricia
Balboa, Ana María
Nicolini, Humberto
Type
text::journal::journal article
Abstract
Introduction. The study of autistic spectrum disorders (ASD) at the genetic level is extremely important to understand their origin. In Mexico, there are few works addressed from this perspective. Objective. We investigated the role of the Brain Derived Neurotrophic Factor (BDNF) gene variant rs6265 G/A for single nucleotide polymorphism analysis in Mexican children with ASD using a case-control association design. Method. We made a pilot study by case-control analysis adjusting by gender, age, and ancestry. Results. Our study found no association between the BDNF rs6265 gene polymorphism and ASD [p = .419, OR = 1.597 (.514, 4.967)]. Discussion and conclusion. Worldwide, the results of case-control association studies with the rs6265 of BDNF are controversial and do not always replicate. This may be due to the ethnicity of our population and additional factors not studied in the present work. Our study suggests that the SNP rs6265 is not contributing for ASD susceptibility in Mexican population.