Prevention of surgical adhesion formation with colchicine on a rat model
Journal
European Surgical Research
ISSN
1421-9921
Date Issued
2003
Author(s)
López Gutiérrez, J.
Elizondo Hinojosa, J.I.
Jáuregui Soto, A.J.
Díaz Martínez, M.
Alcocer Gouyonet, F.
Pérez García, R.
Type
Resource Types::text::conference output::conference proceedings::conference paper
Abstract
Introduction: Colchicine is an alkaloid of Colchicum autumnale. The drug decreases leukocyte motility, phagocytosis, and lactic acid production, and also binds microtubular proteins. Because of lack of phagocytes, a subsequent reduction in proinflammatory enzymes that are present during phagocytosis occurs and the cycle that leads to the inflammatory process is interrupted. Also decreases fibrotic tissue by interfering with collagen secretion. Postsurgical adhesions are found in 94.3% of patients who had abdominal surgery. After surgery, peritoneal reparation begins, increasing leukocytes and macrophages, also developing an inflammatory exudate. Develops a fibrin matrix, which is the main factor in adhesion developing