Heat-shock protein (HSP70-2) allelic frequencies in three distinct Mexican populations

Journal
Genes & Immunity
ISSN
1466-4879
1476-5470
Date Issued
1999
Author(s)
Zúñiga, J.
Vargas Alarcón, Gilberto
Osnaya, N.
Martínez Tripp, S.
Rodríguez-Reyna, T.S.
Hernández-Martinez, B.
Hesiquio, Ramiro
Hernández-Pacheco, G.
Gamboa, R.
Juárez, F.
Salgado, N.
Granados, J.
Type
text::journal::journal article
DOI
URL
Abstract
The major histocompatibility complex (MHC) genes are highly polymorphic and therefore have been useful in population genetics and disease association studies. We analyzed restriction fragment length polymorphism of HSP70-2 alleles in healthy unrelated Mestizo, Mazatecan and Nahua populations. Both Indian groups, Mazatecans and Nahuas, were in Hardy-Weinberg equilibrium, while Mestizos were in disequilibrium (chi 2 = 0.399; P < 0.05). The Mazatecan Indians presented a high frequency of BB homozygosity (17.35%) compared to Mestizos (5%) (P = 0.01). Mexican ethnic groups present differences in distribution of BB genotype. The low frequency of BB genotype in Mestizos may be the result of a negative selection process. ©Genes & Immunity