Time to antibiotic initiation for suspected chorioamnionitis and factors associated with delayed treatment

Lumbreras-Márquez, Mario Isaac; Hale, John; Rowse, Olivia; Villela-Franyutti, Diego; Pearson, Jeffrey C.; Mohammadi, Somayeh; Murthy, Anarghya; Woods, Gregory T.; Diouf, Khady; Farber, Michaela K.

doi:10.1016/j.ajogmf.2023.100871

Time to antibiotic initiation for suspected chorioamnionitis and factors associated with delayed treatment

Journal

American Journal of Obstetrics and Gynecology

ISSN

2589-9333

Date Issued

2023

Author(s)

Hale, John

Rowse, Olivia

Villela-Franyutti, Diego

Pearson, Jeffrey C.

Mohammadi, Somayeh

Murthy, Anarghya

Woods, Gregory T.

Diouf, Khady

Farber, Michaela K.

Type

Resource Types::text::journal::journal article

DOI

10.1016/j.ajogmf.2023.100871

URL

https://scripta.up.edu.mx/handle/20.500.12552/3654

Abstract

Intraamniotic infection can be associated with maternal bacteremia in 10% of cases. Prompt initiation of antibiotic treatment is critical to prevent maternal and fetal complications. At our quaternary center, the primary antibiotic regimen for suspected chorioamnionitis is ampicillin plus gentamicin. A preliminary quality improvement (QI) initiative evaluating the time from fever onset to antibiotic (ie, ampicillin and gentamicin) initiation in laboring patients at our institution suggested frequent delays of ≥1 hour for gentamicin. The aim of the present QI study was to determine the time to gentamicin treatment and specific factors associated with delayed gentamicin administration among patients with a new diagnosis of suspected chorioamnionitis.