Teratogenic Effect of Ethylene Glycol-Methyl Cellosolve Mixture in Rats. I. Reproductive Damage

Arteaga Martínez, Sebastián Manuel; García-Peláez, Isabel; Aguirre-Luna, Oswaldo M.; Saavedra-Ontiveros, Dolores

doi:10.4067/s0717-95022010000400016

Teratogenic Effect of Ethylene Glycol-Methyl Cellosolve Mixture in Rats. I. Reproductive Damage

Journal

International Journal of Morphology

ISSN

0717-9502

Date Issued

2010

Author(s)

Arteaga Martínez, Sebastián Manuel

Facultad de Ciencias de la Salud - CampCM

García-Peláez, Isabel

Facultad de Ciencias de la Salud - CampCM

Aguirre-Luna, Oswaldo M.

Saavedra-Ontiveros, Dolores

Type

text::journal::journal article

DOI

10.4067/s0717-95022010000400016

URL

https://scripta.up.edu.mx/handle/20.500.12552/3702

Abstract

We investigated the reproductive damage and teratogenic effect of an ethylene glycol-methyl cellosolve mixture on gestating Wistar rats, which received a daily intraperitoneal dose of different concentration of the mixture on day 8 of gestation until day 20. In rats treated with the mixture the number of live fetuses decreased and reabsorptions increased with increasing concentrations of the mixture, as well as the number of abnormal fetuses. We conclude that the ethylene glycol-methyl cellosolve mixture possesses a higher teratogenic potential than each of its constituents separately, producing reproductive damage, external fetal abnormalities, growth delay, and increased fetal death.