Brain-gut interaction in irritable bowel syndrome: new findings of a multicomponent disease model

Schmulson, Max J.

Brain-gut interaction in irritable bowel syndrome: new findings of a multicomponent disease model

Journal

The Israel Medical Association journal : IMAJ

ISSN

1565-1088

Date Issued

2001-02

Author(s)

Schmulson, Max J.

Facultad de Ciencias de la Salud - CampCM

Type

text::journal::journal article::review article

URL

https://scripta.up.edu.mx/handle/20.500.12552/3903

Abstract

Knowledge on the pathophysiology of irritable bowel syndrome has evolved, beginning with disturbances in motility to visceral hypersensitivity, and ultimately to alterations in brain-gut bi-directional communication, where neurotransmitters such as serotonin play a key role. Recently, a multicomponent disease model that integrates all these alterations was proposed. This model is divided into physiological, cognitive, emotional and behavioral components that explain the gastrointestinal as well as the constitutional symptoms. In recent years there has been an explosion of research together with new developments in pharmacological treatments for IBS that support each component of this model. This review presents recent data in favor of these alterations in IBS.